2jwt

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[[Image:2jwt.png|left|200px]]
 
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{{STRUCTURE_2jwt| PDB=2jwt | SCENE= }}
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==Solution structure of Engrailed homeodomain WT==
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<StructureSection load='2jwt' size='340' side='right'caption='[[2jwt]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2jwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JWT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwt OCA], [https://pdbe.org/2jwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jwt RCSB], [https://www.ebi.ac.uk/pdbsum/2jwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jwt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HMEN_DROME HMEN_DROME] This protein specifies the body segmentation pattern. It is required for the development of the central nervous system. Transcriptional regulator that represses activated promoters. Wg signaling operates by inactivating the SGG repression of EN autoactivation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/2jwt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jwt ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Two methods are currently available to solve high resolution protein structures-X-ray crystallography and nuclear magnetic resonance (NMR). Both methods usually produce highly similar structures, but small differences between both solutions are always observed. Here the raw NMR data as well as the solved NMR structure were compared to the multiple crystal structures solved for the WT 60 residue three helix bundle engrailed homeodomain (EnHD) and single point mutants. There was excellent agreement between TALOS-predicted and crystal structure-observed dihedral angles and a good agreement for the (3) J(H ( N ) H ( alpha )) couplings for the multiple crystal structures. Around 1% of NOEs were violated for any crystal structure, but no NOE was inconsistent with all of the crystal structures. Violations usually occurred for surface residues or for residues for which multiple discreet conformations were observed between the crystal structures. Comparison of the disorder shown in the multiple crystal structures shows little correlation with dynamics under native conditions for this protein.
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===Solution structure of Engrailed homeodomain WT===
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Comparison of multiple crystal structures with NMR data for engrailed homeodomain.,Religa TL J Biomol NMR. 2008 Mar;40(3):189-202. Epub 2008 Feb 15. PMID:18274703<ref>PMID:18274703</ref>
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{{ABSTRACT_PUBMED_18274703}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2jwt" style="background-color:#fffaf0;"></div>
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[[2jwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWT OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:018274703</ref><references group="xtra"/>
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Religa, T L.]]
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[[Category: Large Structures]]
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[[Category: Developmental protein]]
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[[Category: Religa TL]]
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[[Category: Dna-binding]]
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[[Category: Homeobox]]
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[[Category: Homeodomain]]
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[[Category: Nucleus]]
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[[Category: Phosphorylation]]
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[[Category: Repressor]]
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[[Category: Segmentation polarity protein]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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Current revision

Solution structure of Engrailed homeodomain WT

PDB ID 2jwt

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OCA

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