2fc8

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[[Image:2fc8.png|left|200px]]
 
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{{STRUCTURE_2fc8| PDB=2fc8 | SCENE= }}
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==Solution structure of the RRM_1 domain of NCL protein==
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<StructureSection load='2fc8' size='340' side='right'caption='[[2fc8]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2fc8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FC8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fc8 OCA], [https://pdbe.org/2fc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fc8 RCSB], [https://www.ebi.ac.uk/pdbsum/2fc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fc8 ProSAT], [https://www.topsan.org/Proteins/RSGI/2fc8 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NUCL_HUMAN NUCL_HUMAN] Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.<ref>PMID:10393184</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/2fc8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fc8 ConSurf].
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<div style="clear:both"></div>
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===Solution structure of the RRM_1 domain of NCL protein===
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==See Also==
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*[[Nucleolin|Nucleolin]]
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== References ==
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==About this Structure==
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<references/>
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[[2fc8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FC8 OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dang, W.]]
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[[Category: Large Structures]]
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[[Category: Inoue, M.]]
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[[Category: Dang W]]
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[[Category: Kigawa, T.]]
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[[Category: Inoue M]]
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[[Category: Muto, Y.]]
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[[Category: Kigawa T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Muto Y]]
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[[Category: Shirouzu, M.]]
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[[Category: Shirouzu M]]
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[[Category: Terada, T.]]
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[[Category: Terada T]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Ncl protein]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rna binding protein]]
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[[Category: Rrm_1 domain]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Structure genomic]]
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Current revision

Solution structure of the RRM_1 domain of NCL protein

PDB ID 2fc8

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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