2l8w

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[[Image:2l8w.png|left|200px]]
 
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{{STRUCTURE_2l8w| PDB=2l8w | SCENE= }}
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==r(CCGCUGCGG)2 UU Internal Loop Found in Myotonic Dystrophy Type 1 - UU pair with two hydrogen bond pairs==
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<StructureSection load='2l8w' size='340' side='right'caption='[[2l8w]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2l8w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L8W FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8w OCA], [https://pdbe.org/2l8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l8w RCSB], [https://www.ebi.ac.uk/pdbsum/2l8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l8w ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The NMR structure of an RNA with a copy of the 5'CUG/3'GUC motif found in the triplet repeating disorder myotonic dystrophy type 1 (DM1) is disclosed. The lowest energy conformation of the UU pair is a single-hydrogen bond structure; however, the UU protons undergo exchange indicating structural dynamics. Molecular dynamics simulations show that the single hydrogen bond structure is the most populated one but the UU pair interconverts among zero, one, and two hydrogen bond pairs. These studies have implications for the recognition of the DM1 RNA by small molecules and proteins.
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===r(CCGCUGCGG)2 UU Internal Loop Found in Myotonic Dystrophy Type 1 - UU pair with two hydrogen bond pairs===
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NMR Spectroscopy and Molecular Dynamics Simulation of r(CCGCUGCGG)(2) Reveal a Dynamic UU Internal Loop Found in Myotonic Dystrophy Type 1.,Parkesh R, Fountain M, Disney MD Biochemistry. 2011 Feb 8;50(5):599-601. Epub 2011 Jan 13. PMID:21204525<ref>PMID:21204525</ref>
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{{ABSTRACT_PUBMED_21204525}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2l8w" style="background-color:#fffaf0;"></div>
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[[2l8w]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8W OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:021204525</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Disney, M.]]
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[[Category: Large Structures]]
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[[Category: Fountain, M.]]
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[[Category: Synthetic construct]]
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[[Category: Parkesh, R.]]
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[[Category: Disney M]]
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[[Category: Rna]]
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[[Category: Fountain M]]
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[[Category: Uu mismatch]]
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[[Category: Parkesh R]]

Current revision

r(CCGCUGCGG)2 UU Internal Loop Found in Myotonic Dystrophy Type 1 - UU pair with two hydrogen bond pairs

PDB ID 2l8w

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