2gkm

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[[Image:2gkm.png|left|200px]]
 
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{{STRUCTURE_2gkm| PDB=2gkm | SCENE= }}
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==Crystal structure of Mycobacterium tuberculosis trHbN TyrB10Phe mutant==
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<StructureSection load='2gkm' size='340' side='right'caption='[[2gkm]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
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===Crystal structure of Mycobacterium tuberculosis trHbN TyrB10Phe mutant===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2gkm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GKM FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16846220}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.731&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gkm OCA], [https://pdbe.org/2gkm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gkm RCSB], [https://www.ebi.ac.uk/pdbsum/2gkm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gkm ProSAT]</span></td></tr>
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[[2gkm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKM OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/TRHBN_MYCTU TRHBN_MYCTU] Binds oxygen cooperatively with very high affinity (P(50) = 0.013 mmHg at 20 degrees Celsius) because of a fast combination (25 microM(-1).s(-1)) and a slow dissociation (0.2 s(-1)) rate.
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<ref group="xtra">PMID:016846220</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gk/2gkm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gkm ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Bolognesi, M.]]
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[[Category: Bolognesi M]]
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[[Category: Milani, M.]]
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[[Category: Milani M]]
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[[Category: Mutant]]
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[[Category: Oxygen storage-transport complex]]
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[[Category: Truncated hemoglobin]]
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Current revision

Crystal structure of Mycobacterium tuberculosis trHbN TyrB10Phe mutant

PDB ID 2gkm

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