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2kaw

From Proteopedia

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[[Image:2kaw.png|left|200px]]
 
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{{STRUCTURE_2kaw| PDB=2kaw | SCENE= }}
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==NMR structure of the mDvl1 PDZ domain in complex with its inhibitor==
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<StructureSection load='2kaw' size='340' side='right'caption='[[2kaw]]' scene=''>
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===NMR structure of the mDvl1 PDZ domain in complex with its inhibitor===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kaw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KAW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SUZ:[(1Z)-5-FLUORO-2-METHYL-1-{4-[METHYLSULFINYL]BENZYLIDENE}-1H-INDEN-3-YL]ACETIC+ACID'>SUZ</scene></td></tr>
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[[2kaw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KAW OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kaw OCA], [https://pdbe.org/2kaw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kaw RCSB], [https://www.ebi.ac.uk/pdbsum/2kaw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kaw ProSAT]</span></td></tr>
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</table>
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==Reference==
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== Function ==
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<ref group="xtra">PMID:019637179</ref><references group="xtra"/>
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[https://www.uniprot.org/uniprot/DVL1_MOUSE DVL1_MOUSE] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).<ref>PMID:12165471</ref> <ref>PMID:15353129</ref> <ref>PMID:11101902</ref> <ref>PMID:19637179</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ka/2kaw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kaw ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Lee, H J.]]
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[[Category: Lee HJ]]
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[[Category: Shao, Y.]]
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[[Category: Shao Y]]
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[[Category: Shi, D L.]]
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[[Category: Shi DL]]
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[[Category: Wang, N X.]]
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[[Category: Wang NX]]
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[[Category: Zheng, J J.]]
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[[Category: Zheng JJ]]
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[[Category: Developmental protein]]
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[[Category: Inhibitor of protein-protein interaction]]
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[[Category: Pdz domain]]
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[[Category: Protein structure]]
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[[Category: Signaling protein]]
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[[Category: Wnt signaling]]
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[[Category: Wnt signaling pathway]]
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Current revision

NMR structure of the mDvl1 PDZ domain in complex with its inhibitor

PDB ID 2kaw

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