2je0

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[[Image:2je0.png|left|200px]]
 
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{{STRUCTURE_2je0| PDB=2je0 | SCENE= }}
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==Crystal Structure of pp32==
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<StructureSection load='2je0' size='340' side='right'caption='[[2je0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF PP32===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2je0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JE0 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17567741}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2je0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2je0 OCA], [https://pdbe.org/2je0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2je0 RCSB], [https://www.ebi.ac.uk/pdbsum/2je0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2je0 ProSAT]</span></td></tr>
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[[2je0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JE0 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/AN32A_HUMAN AN32A_HUMAN] Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.<ref>PMID:15642345</ref> <ref>PMID:10400610</ref> <ref>PMID:11360199</ref> <ref>PMID:17557114</ref>
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<ref group="xtra">PMID:017567741</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/je/2je0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2je0 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Huyton, T.]]
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[[Category: Large Structures]]
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[[Category: Wolberger, C.]]
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[[Category: Huyton T]]
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[[Category: Nuclear protein]]
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[[Category: Wolberger C]]

Current revision

Crystal Structure of pp32

PDB ID 2je0

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