2l35

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[[Image:2l35.png|left|200px]]
 
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{{STRUCTURE_2l35| PDB=2l35 | SCENE= }}
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==Structure of the DAP12-NKG2C transmembrane heterotrimer==
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<StructureSection load='2l35' size='340' side='right'caption='[[2l35]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2l35]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L35 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l35 OCA], [https://pdbe.org/2l35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l35 RCSB], [https://www.ebi.ac.uk/pdbsum/2l35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l35 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TYOBP_HUMAN TYOBP_HUMAN] Nasu-Hakola disease. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/TYOBP_HUMAN TYOBP_HUMAN] Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.[https://www.uniprot.org/uniprot/NKG2C_HUMAN NKG2C_HUMAN] Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy (PubMed:30134159, PubMed:37264229, PubMed:9754572). Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection (PubMed:20952657, PubMed:21825173). Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation (PubMed:15940674, PubMed:9655483).<ref>PMID:15940674</ref> <ref>PMID:20952657</ref> <ref>PMID:21825173</ref> <ref>PMID:30134159</ref> <ref>PMID:37264229</ref> <ref>PMID:9655483</ref> <ref>PMID:9754572</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Many receptors that activate cells of the immune system are multisubunit membrane protein complexes in which ligand recognition and signaling functions are contributed by separate protein modules. Receptors and signaling subunits assemble through contacts among basic and acidic residues in their transmembrane domains to form the functional complexes. Here we report the nuclear magnetic resonance (NMR) structure of the membrane-embedded, heterotrimeric assembly formed by association of the DAP12 signaling module with the natural killer (NK) cell-activating receptor NKG2C. The main intramembrane contact site is formed by a complex electrostatic network involving five hydrophilic transmembrane residues. Functional mutagenesis demonstrated that similar polar intramembrane motifs are also important for assembly of the NK cell-activating NKG2D-DAP10 complex and the T cell antigen receptor (TCR)-invariant signaling protein CD3 complex. This structural motif therefore lies at the core of the molecular organization of many activating immunoreceptors.
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===Structure of the DAP12-NKG2C transmembrane heterotrimer===
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The structural basis for intramembrane assembly of an activating immunoreceptor complex.,Call ME, Wucherpfennig KW, Chou JJ Nat Immunol. 2010 Nov;11(11):1023-9. Epub 2010 Oct 3. PMID:20890284<ref>PMID:20890284</ref>
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{{ABSTRACT_PUBMED_20890284}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2l35" style="background-color:#fffaf0;"></div>
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[[2l35]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L35 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:020890284</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Call, M E.]]
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[[Category: Large Structures]]
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[[Category: Chou, J J.]]
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[[Category: Call ME]]
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[[Category: Wucherpfennig, K W.]]
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[[Category: Chou JJ]]
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[[Category: Dap12-nkg2c complex]]
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[[Category: Wucherpfennig KW]]
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[[Category: Immunoreceptor]]
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[[Category: Protein binding]]
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[[Category: Transmembrane assembly]]
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Current revision

Structure of the DAP12-NKG2C transmembrane heterotrimer

PDB ID 2l35

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