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1w6i

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[[Image:1w6i.gif|left|200px]]<br /><applet load="1w6i" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1w6i, resolution 2.70&Aring;" />
 
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'''PLASMEPSIN II-PEPSTATIN A COMPLEX'''<br />
 
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==About this Structure==
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==plasmepsin II-pepstatin A complex==
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1W6I is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum] with <scene name='pdbligand=IHN:'>IHN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Plasmepsin_II Plasmepsin II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.39 3.4.23.39] Known structural/functional Site: <scene name='pdbsite=AC1:Ihn+Binding+Site+For+Chain+C'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W6I OCA].
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<StructureSection load='1w6i' size='340' side='right'caption='[[1w6i]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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[[Category: Plasmepsin II]]
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== Structural highlights ==
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[[Category: Plasmodium falciparum]]
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<table><tr><td colspan='2'>[[1w6i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum] and [https://en.wikipedia.org/wiki/Streptomyces_argenteolus_subsp._toyonakensis Streptomyces argenteolus subsp. toyonakensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W6I FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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[[Category: Johansson, P O.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>
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[[Category: Kvarnstroem, I.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w6i OCA], [https://pdbe.org/1w6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w6i RCSB], [https://www.ebi.ac.uk/pdbsum/1w6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w6i ProSAT]</span></td></tr>
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[[Category: Lindberg, J.]]
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</table>
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[[Category: Rosenquist, A.]]
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== Function ==
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[[Category: Samuelsson, L Vrang B.]]
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[https://www.uniprot.org/uniprot/PLM2_PLAFX PLM2_PLAFX] During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation (PubMed:8844673, PubMed:11782538, PubMed:15574427). May cleave preferentially denatured hemoglobin that has been cleaved by PMI (PubMed:8844673). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).<ref>PMID:11782538</ref> <ref>PMID:15574427</ref> <ref>PMID:8844673</ref>
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[[Category: Unge, T.]]
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== Evolutionary Conservation ==
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[[Category: IHN]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: aspartic protease]]
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Check<jmol>
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[[Category: drug]]
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<jmolCheckbox>
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[[Category: glycoprotein]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w6/1w6i_consurf.spt"</scriptWhenChecked>
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[[Category: hydrolase]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: malaria]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: plasmepsin]]
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w6i ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:41:02 2008''
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==See Also==
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*[[Plasmepsin|Plasmepsin]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Plasmodium falciparum]]
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[[Category: Streptomyces argenteolus subsp. toyonakensis]]
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[[Category: Johansson P-O]]
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[[Category: Kvarnstroem I]]
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[[Category: Lindberg J]]
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[[Category: Rosenquist A]]
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[[Category: Samuelsson B]]
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[[Category: Unge T]]
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[[Category: Vrang L]]

Current revision

plasmepsin II-pepstatin A complex

PDB ID 1w6i

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