2ot2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2ot2" [edit=sysop:move=sysop])
Current revision (19:13, 29 May 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2ot2.png|left|200px]]
 
-
{{STRUCTURE_2ot2| PDB=2ot2 | SCENE= }}
+
==Solution Structure of HypC==
 +
<StructureSection load='2ot2' size='340' side='right'caption='[[2ot2]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2ot2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OT2 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ot2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ot2 OCA], [https://pdbe.org/2ot2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ot2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ot2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ot2 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HYPC_ECOLI HYPC_ECOLI] Is required for the formation of all three hydrogenase isoenzymes. May bind to the precursor form of the large subunit of dehydrogenases to keep them in a conformation accessible for metal incorporation.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ot/2ot2_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ot2 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Escherichia coli HypC plays an important role in the maturation process of the pre-maturated HycE, the large subunit of hydrogenase 3. It serves as an iron transfer as well as a chaperone protein during the maturation process of pre-HycE, and interacts with both HypD and HycE. The N-terminal cysteine residue of HypC plays a key role in the protein-protein interactions. Here, we present the three-dimensional structure of E. coli HypC, the first solution structure of HupF/HypC family. Our result demonstrates that E. coli HypC consists of a typical OB-fold beta-barrel with two C-terminal helixes. Sequence alignment and structural comparison reveal that the hydrophobic region on the surface of E. coli HypC, as well as the highly flexible C-terminal helixes, may involve in the interactions of E. coli HypC with other proteins.
-
===Solution Structure of HypC===
+
Solution structure of Escherichia coli HypC.,Wang L, Xia B, Jin C Biochem Biophys Res Commun. 2007 Sep 28;361(3):665-9. Epub 2007 Jul 26. PMID:17669368<ref>PMID:17669368</ref>
-
{{ABSTRACT_PUBMED_17669368}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2ot2" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
[[2ot2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OT2 OCA].
+
*[[HypA%2C HypB%2C HypC%2C HypD%2C HypE and HypF 3D structures|HypA%2C HypB%2C HypC%2C HypD%2C HypE and HypF 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:017669368</ref><references group="xtra"/>
+
__TOC__
-
[[Category: Escherichia coli k-12]]
+
</StructureSection>
-
[[Category: Jin, C.]]
+
[[Category: Escherichia coli K-12]]
-
[[Category: Wang, L.]]
+
[[Category: Large Structures]]
-
[[Category: Beta barrel]]
+
[[Category: Jin C]]
-
[[Category: Chaperone]]
+
[[Category: Wang L]]

Current revision

Solution Structure of HypC

PDB ID 2ot2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ot2"
Personal tools