2g9l

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2g9l" [edit=sysop:move=sysop])
Current revision (07:54, 23 October 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2g9l.png|left|200px]]
 
-
{{STRUCTURE_2g9l| PDB=2g9l | SCENE= }}
+
==The High-resolution Solution Conformation of an Antimicrobial Peptide Gaegurin 4 and Its Mode of Membrane Interaction==
 +
<StructureSection load='2g9l' size='340' side='right'caption='[[2g9l]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2g9l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Glandirana_rugosa Glandirana rugosa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G9L FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9l OCA], [https://pdbe.org/2g9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g9l RCSB], [https://www.ebi.ac.uk/pdbsum/2g9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g9l ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GGN4_GLARU GGN4_GLARU] Has a non-hemolytic activity. Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
We have applied NMR spectroscopy to determine the high-resolution structure of gaegurin 4, a 37-residue antimicrobial peptide from Rana rugosa, under varying hydrophobic conditions. Even in 100% H2O, gaegurin 4 contains a nascent turn near its C-terminal Rana box. Under a more hydrophobic condition it forms two amphipathic helices, one long encompassing residues 2-23 and the other consisting of residues 25-34, similar to what has been observed in cecropin A. Functional implication of the helix-breaking kink at Gly24 in gaegurin 4 was investigated by preparing several analogs. Based upon the current and previous results, we propose a novel seaanemone-like ion pore-forming model for gaegurin 4.
-
===The High-resolution Solution Conformation of an Antimicrobial Peptide Gaegurin 4 and Its Mode of Membrane Interaction===
+
Solution structure and membrane interaction mode of an antimicrobial peptide gaegurin 4.,Chi SW, Kim JS, Kim DH, Lee SH, Park YH, Han KH Biochem Biophys Res Commun. 2007 Jan 19;352(3):592-7. Epub 2006 Nov 27. PMID:17141187<ref>PMID:17141187</ref>
-
{{ABSTRACT_PUBMED_17141187}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 2g9l" style="background-color:#fffaf0;"></div>
-
[[2g9l]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9L OCA].
+
== References ==
-
[[Category: Chi, S W.]]
+
<references/>
-
[[Category: Han, K H.]]
+
__TOC__
-
[[Category: Amphipathic helix]]
+
</StructureSection>
-
[[Category: Antibiotic]]
+
[[Category: Glandirana rugosa]]
 +
[[Category: Large Structures]]
 +
[[Category: Chi S-W]]
 +
[[Category: Han K-H]]

Current revision

The High-resolution Solution Conformation of an Antimicrobial Peptide Gaegurin 4 and Its Mode of Membrane Interaction

PDB ID 2g9l

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2g9l"
Personal tools