2pni

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[[Image:2pni.png|left|200px]]
 
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{{STRUCTURE_2pni| PDB=2pni | SCENE= }}
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==SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE==
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<StructureSection load='2pni' size='340' side='right'caption='[[2pni]]' scene=''>
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===SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2pni]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PNI FirstGlance]. <br>
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{{ABSTRACT_PUBMED_7684655}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pni OCA], [https://pdbe.org/2pni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pni RCSB], [https://www.ebi.ac.uk/pdbsum/2pni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pni ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2pni]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNI OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/P85A_BOVIN P85A_BOVIN] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pn/2pni_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pni ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phsphatidylinositol 3-kinase|Phsphatidylinositol 3-kinase]]
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*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:007684655</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Booker, G W.]]
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[[Category: Large Structures]]
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[[Category: Boyd, J.]]
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[[Category: Booker GW]]
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[[Category: Campbell, I D.]]
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[[Category: Boyd J]]
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[[Category: Downing, A K.]]
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[[Category: Campbell ID]]
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[[Category: Driscoll, P C.]]
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[[Category: Downing AK]]
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[[Category: Gout, I.]]
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[[Category: Driscoll PC]]
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[[Category: Waterfield, M D.]]
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[[Category: Gout I]]
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[[Category: Phosphotransferase]]
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[[Category: Waterfield MD]]

Current revision

SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE

PDB ID 2pni

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