2gw8

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[[Image:2gw8.png|left|200px]]
 
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{{STRUCTURE_2gw8| PDB=2gw8 | SCENE= }}
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==Structure of the PII signal transduction protein of Neisseria meningitidis at 1.85 resolution==
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<StructureSection load='2gw8' size='340' side='right'caption='[[2gw8]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2gw8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis_MC58 Neisseria meningitidis MC58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GW8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gw8 OCA], [https://pdbe.org/2gw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gw8 RCSB], [https://www.ebi.ac.uk/pdbsum/2gw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gw8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9JXK6_NEIMB Q9JXK6_NEIMB]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/2gw8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gw8 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The P(II) signal transduction proteins GlnB and GlnK are implicated in the regulation of nitrogen assimilation in Escherichia coli and other enteric bacteria. P(II)-like proteins are widely distributed in bacteria, archaea and plants. In contrast to other bacteria, Neisseria are limited to a single P(II) protein (NMB 1995), which shows a high level of sequence identity to GlnB and GlnK from Escherichia coli (73 and 62%, respectively). The structure of the P(II) protein from N. meningitidis (serotype B) has been solved by molecular replacement to a resolution of 1.85 A. Comparison of the structure with those of other P(II) proteins shows that the overall fold is tightly conserved across the whole population of related proteins, in particular the positions of the residues implicated in ATP binding. It is proposed that the Neisseria P(II) protein shares functions with GlnB/GlnK of enteric bacteria.
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===Structure of the PII signal transduction protein of Neisseria meningitidis at 1.85 resolution===
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Structure of the PII signal transduction protein of Neisseria meningitidis at 1.85 A resolution.,Nichols CE, Sainsbury S, Berrow NS, Alderton D, Saunders NJ, Stammers DK, Owens RJ Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jun 1;62(Pt, 6):494-7. Epub 2006 May 31. PMID:16754965<ref>PMID:16754965</ref>
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{{ABSTRACT_PUBMED_16754965}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2gw8" style="background-color:#fffaf0;"></div>
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[[2gw8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GW8 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016754965</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Neisseria meningitidis]]
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[[Category: Large Structures]]
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[[Category: Alderton, D.]]
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[[Category: Neisseria meningitidis MC58]]
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[[Category: Berrow, N S.]]
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[[Category: Alderton D]]
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[[Category: Nichols, C E.]]
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[[Category: Berrow NS]]
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[[Category: OPPF, Oxford Protein Production Facility.]]
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[[Category: Nichols CE]]
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[[Category: Owens, R J.]]
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[[Category: Owens RJ]]
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[[Category: Sainsbury, S.]]
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[[Category: Sainsbury S]]
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[[Category: Stammers, D K.]]
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[[Category: Stammers DK]]
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[[Category: Neisseria]]
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[[Category: Oppf]]
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[[Category: Oxford protein production facility]]
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[[Category: Pii]]
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[[Category: Signal transduction]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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[[Category: Transcriptional regulation]]
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Current revision

Structure of the PII signal transduction protein of Neisseria meningitidis at 1.85 resolution

PDB ID 2gw8

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