2jug

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[[Image:2jug.png|left|200px]]
 
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{{STRUCTURE_2jug| PDB=2jug | SCENE= }}
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==Multienzyme Docking in Hybrid Megasynthetases==
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<StructureSection load='2jug' size='340' side='right'caption='[[2jug]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2jug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Archangium_disciforme Archangium disciforme]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JUG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jug OCA], [https://pdbe.org/2jug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jug RCSB], [https://www.ebi.ac.uk/pdbsum/2jug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jug ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5ZPA9_9BACT Q5ZPA9_9BACT]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/2jug_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jug ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hybrid multienzyme systems composed of polyketide synthase (PKS) and nonribosomal polypeptide synthetase (NRPS) modules direct the biosynthesis of clinically valuable natural products in bacteria. The fidelity of this process depends on specific recognition between successive polypeptides in each assembly line-interactions that are mediated by terminal 'docking domains'. We have identified a new family of N-terminal docking domains, exemplified by TubCdd from the tubulysin system of Angiococcus disciformis An d48. TubCdd is homodimeric, which suggests that NRPS subunits in mixed systems self-associate to interact with partner PKS homodimers. The NMR structure of TubCdd reveals a new fold featuring an exposed beta-hairpin that serves as the binding site for the C-terminal docking domain of the partner polypeptide. The pattern of charged residues on the contact surface of the beta-hairpin is a key determinant of the interaction and seems to constitute a 'docking code' that can be used to alter binding affinity.
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===Multienzyme Docking in Hybrid Megasynthetases===
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Multienzyme docking in hybrid megasynthetases.,Richter CD, Nietlispach D, Broadhurst RW, Weissman KJ Nat Chem Biol. 2008 Jan;4(1):75-81. Epub 2007 Dec 9. PMID:18066054<ref>PMID:18066054</ref>
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{{ABSTRACT_PUBMED_18066054}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2jug" style="background-color:#fffaf0;"></div>
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[[2jug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Angiococcus_disciformis Angiococcus disciformis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUG OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:018066054</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Angiococcus disciformis]]
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[[Category: Archangium disciforme]]
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[[Category: Broadhurst, R W.]]
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[[Category: Large Structures]]
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[[Category: Nietlispach, D.]]
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[[Category: Broadhurst RW]]
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[[Category: Richter, C D.]]
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[[Category: Nietlispach D]]
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[[Category: Weissman, K J.]]
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[[Category: Richter CD]]
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[[Category: Biosynthetic protein]]
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[[Category: Weissman KJ]]
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[[Category: Dimer]]
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[[Category: Docking domain]]
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[[Category: Ligase]]
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[[Category: Nonribosomal peptide synthetase]]
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[[Category: Phosphopantetheine]]
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[[Category: Tubulysin]]
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Current revision

Multienzyme Docking in Hybrid Megasynthetases

PDB ID 2jug

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