2k6y

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[[Image:2k6y.png|left|200px]]
 
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{{STRUCTURE_2k6y| PDB=2k6y | SCENE= }}
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==Solution structures of apo form PCuA (cis conformation of the peptide bond involving the nitrogen of P14)==
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<StructureSection load='2k6y' size='340' side='right'caption='[[2k6y]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2k6y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K6Y FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k6y OCA], [https://pdbe.org/2k6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k6y RCSB], [https://www.ebi.ac.uk/pdbsum/2k6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k6y ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5SGY7_THET8 Q5SGY7_THET8]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/2k6y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k6y ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Copper is essential for proper functioning of cytochrome c oxidases, and therefore for cellular respiration in eukaryotes and many bacteria. Here we show that a new periplasmic protein (PCu(A)C) selectively inserts Cu(I) ions into subunit II of Thermus thermophilus ba(3) oxidase to generate a native Cu(A) site. The purported metallochaperone Sco1 is unable to deliver copper ions; instead, it works as a thiol-disulfide reductase to maintain the correct oxidation state of the Cu(A) cysteine ligands.
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===Solution structures of apo form PCuA (cis conformation of the peptide bond involving the nitrogen of P14)===
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Mechanism of Cu(A) assembly.,Abriata LA, Banci L, Bertini I, Ciofi-Baffoni S, Gkazonis P, Spyroulias GA, Vila AJ, Wang S Nat Chem Biol. 2008 Oct;4(10):599-601. Epub 2008 Aug 31. PMID:18758441<ref>PMID:18758441</ref>
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{{ABSTRACT_PUBMED_18758441}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2k6y" style="background-color:#fffaf0;"></div>
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[[2k6y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6Y OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:018758441</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Thermus thermophilus]]
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[[Category: Large Structures]]
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[[Category: Abriata, L A.]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Banci, L.]]
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[[Category: Abriata LA]]
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[[Category: Bertini, I.]]
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[[Category: Banci L]]
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[[Category: Ciofi-Baffoni, S.]]
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[[Category: Bertini I]]
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[[Category: Gkazonis, P.]]
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[[Category: Ciofi-Baffoni S]]
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[[Category: Spyroulias, G A.]]
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[[Category: Gkazonis P]]
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[[Category: Vila, A J.]]
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[[Category: Spyroulias GA]]
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[[Category: Wang, S.]]
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[[Category: Vila AJ]]
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[[Category: Cis conformation]]
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[[Category: Wang S]]
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[[Category: Copper transfer protein]]
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[[Category: Metal transport]]
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[[Category: Pcua]]
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Current revision

Solution structures of apo form PCuA (cis conformation of the peptide bond involving the nitrogen of P14)

PDB ID 2k6y

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