2f1d

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[[Image:2f1d.png|left|200px]]
 
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{{STRUCTURE_2f1d| PDB=2f1d | SCENE= }}
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==X-Ray Structure of imidazoleglycerol-phosphate dehydratase==
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<StructureSection load='2f1d' size='340' side='right'caption='[[2f1d]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2f1d]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F1D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F1D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f1d OCA], [https://pdbe.org/2f1d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f1d RCSB], [https://www.ebi.ac.uk/pdbsum/2f1d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f1d ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HIS5A_ARATH HIS5A_ARATH]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/2f1d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f1d ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of A. thaliana imidazoleglycerol-phosphate dehydratase, an enzyme of histidine biosynthesis and a target for the triazole phosphonate herbicides, has been determined to 3.0 A resolution. The structure is composed of 24 identical subunits arranged in 432 symmetry and shows how the formation of a novel dimanganese cluster is crucial to the assembly of the active 24-mer from an inactive trimeric precursor and to the formation of the active site of the enzyme. Molecular modeling suggests that the substrate is bound to the manganese cluster as an imidazolate moiety that subsequently collapses to yield a diazafulvene intermediate. The mode of imidazolate recognition exploits pseudosymmetry at the active site arising from a combination of the assembly of the particle and the pseudosymmetry present in each subunit as a result of gene duplication. This provides an intriguing example of the role of evolution in the design of Nature's catalysts.
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===X-Ray Structure of imidazoleglycerol-phosphate dehydratase===
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Structure and mechanism of imidazoleglycerol-phosphate dehydratase.,Glynn SE, Baker PJ, Sedelnikova SE, Davies CL, Eadsforth TC, Levy CW, Rodgers HF, Blackburn GM, Hawkes TR, Viner R, Rice DW Structure. 2005 Dec;13(12):1809-17. PMID:16338409<ref>PMID:16338409</ref>
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{{ABSTRACT_PUBMED_16338409}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2f1d" style="background-color:#fffaf0;"></div>
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[[2f1d]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F1D OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016338409</ref><references group="xtra"/>
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Imidazoleglycerol-phosphate dehydratase]]
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[[Category: Large Structures]]
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[[Category: Baker, P J.]]
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[[Category: Baker PJ]]
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[[Category: Davies, C L.]]
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[[Category: Davies CL]]
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[[Category: Eadsforth, T C.]]
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[[Category: Eadsforth TC]]
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[[Category: Glynn, S E.]]
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[[Category: Glynn SE]]
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[[Category: Rice, D W.]]
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[[Category: Rice DW]]
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[[Category: Sedelnikova, S E.]]
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[[Category: Sedelnikova SE]]
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[[Category: Herbicide]]
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[[Category: Histidine biosynthesis]]
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[[Category: Igpd]]
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[[Category: Lyase]]
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[[Category: Manganese]]
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Current revision

X-Ray Structure of imidazoleglycerol-phosphate dehydratase

PDB ID 2f1d

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