2hf0
From Proteopedia
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| - | [[Image:2hf0.png|left|200px]] | ||
| - | + | ==Bifidobacterium longum bile salt hydrolase== | |
| - | + | <StructureSection load='2hf0' size='340' side='right'caption='[[2hf0]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2hf0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bifidobacterium_longum Bifidobacterium longum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HF0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hf0 OCA], [https://pdbe.org/2hf0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hf0 RCSB], [https://www.ebi.ac.uk/pdbsum/2hf0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hf0 ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[2hf0]] is a 2 chain structure with sequence from [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/CBH_BIFLN CBH_BIFLN] Bile salt hydrolase that catalyzes the deconjugation of glycine- and taurine-linked bile salts, which occurs naturally in the intestines of humans, releasing amino acid residues and deconjugated bile salts (bile acids). Can hydrolyze the amid bond in all six major human bile salts, namely glycocholate (GCA), glycodeoxycholate (GDCA), glycochenodeoxycholate (GCDCA), taurocholate (TCA), taurodeoxycholate (TDCA) and taurochenodeoxycholate (TCDCA). Shows a slight preference for glycine-conjugated bile acids as substrates (PubMed:10831430, PubMed:16905539). Is totally inactive toward penicillin V (PubMed:16905539).<ref>PMID:10831430</ref> <ref>PMID:16905539</ref> | |
| - | == | + | == Evolutionary Conservation == |
| - | < | + | [[Image:Consurf_key_small.gif|200px|right]] |
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hf/2hf0_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hf0 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Bifidobacterium longum]] | [[Category: Bifidobacterium longum]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Brannigan | + | [[Category: Brannigan JA]] |
| - | [[Category: Kumar | + | [[Category: Kumar RS]] |
| - | [[Category: Suresh | + | [[Category: Suresh CG]] |
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Current revision
Bifidobacterium longum bile salt hydrolase
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