2l0a
From Proteopedia
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| - | [[Image:2l0a.png|left|200px]] | ||
| - | + | ==Solution NMR Structure of Signal transducing adapter molecule 1 STAM-1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4479E== | |
| - | + | <StructureSection load='2l0a' size='340' side='right'caption='[[2l0a]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2l0a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L0A FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0a OCA], [https://pdbe.org/2l0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l0a RCSB], [https://www.ebi.ac.uk/pdbsum/2l0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l0a ProSAT]</span></td></tr> |
| - | [[2l0a]] is a 1 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/STAM1_HUMAN STAM1_HUMAN] Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/2l0a_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2l0a ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Acton | + | [[Category: Large Structures]] |
| - | [[Category: Ciccosanti | + | [[Category: Acton TB]] |
| - | [[Category: Everett | + | [[Category: Ciccosanti C]] |
| - | [[Category: Janjua | + | [[Category: Everett JK]] |
| - | [[Category: Montelione | + | [[Category: Janjua H]] |
| - | + | [[Category: Montelione GT]] | |
| - | [[Category: Rost | + | [[Category: Rost B]] |
| - | [[Category: Shastry | + | [[Category: Shastry R]] |
| - | [[Category: Tang | + | [[Category: Tang Y]] |
| - | [[Category: Xiao | + | [[Category: Xiao R]] |
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Current revision
Solution NMR Structure of Signal transducing adapter molecule 1 STAM-1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4479E
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Categories: Homo sapiens | Large Structures | Acton TB | Ciccosanti C | Everett JK | Janjua H | Montelione GT | Rost B | Shastry R | Tang Y | Xiao R
