This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2kbk
From Proteopedia
(Difference between revisions)
| (6 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:2kbk.png|left|200px]] | ||
| - | + | ==Solution Structure of BmK-M10== | |
| - | + | <StructureSection load='2kbk' size='340' side='right'caption='[[2kbk]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2kbk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KBK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2kbh|2kbh]], [[2kbj|2kbj]]</div></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbk OCA], [https://pdbe.org/2kbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kbk RCSB], [https://www.ebi.ac.uk/pdbsum/2kbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kbk ProSAT]</span></td></tr> |
| - | [[2kbk]] is a 1 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/SCXA_MESMA SCXA_MESMA]] Binds to voltage-dependent sodium channels (Nav) and voltage-dependent delayed rectifier potassium channels and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. Administration to mice at a dosage of 0.8 mg/kg produces an analgesic effect. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/2kbk_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kbk ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mesobuthus martensii]] | [[Category: Mesobuthus martensii]] | ||
| - | [[Category: Wu, H | + | [[Category: Wu, H]] |
| - | [[Category: Zhu, J | + | [[Category: Zhu, J]] |
[[Category: Ionic channel inhibitor]] | [[Category: Ionic channel inhibitor]] | ||
[[Category: Neurotoxin]] | [[Category: Neurotoxin]] | ||
Current revision
Solution Structure of BmK-M10
| |||||||||||
