2kz5

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[[Image:2kz5.png|left|200px]]
 
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{{STRUCTURE_2kz5| PDB=2kz5 | SCENE= }}
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==Solution NMR Structure of Transcription factor NF-E2 subunit's DNA binding domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR4653B==
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<StructureSection load='2kz5' size='340' side='right'caption='[[2kz5]]' scene=''>
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===Solution NMR Structure of Transcription factor NF-E2 subunit's DNA binding domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR4653B===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZ5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz5 OCA], [https://pdbe.org/2kz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kz5 RCSB], [https://www.ebi.ac.uk/pdbsum/2kz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kz5 ProSAT]</span></td></tr>
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[[2kz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ5 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NFE2_HUMAN NFE2_HUMAN] Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.<ref>PMID:11154691</ref> <ref>PMID:16287851</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/2kz5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kz5 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Acton, T B.]]
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[[Category: Large Structures]]
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[[Category: Ciccosanti, C.]]
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[[Category: Acton TB]]
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[[Category: Everett, J K.]]
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[[Category: Ciccosanti C]]
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[[Category: Janjua, H.]]
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[[Category: Everett JK]]
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[[Category: Liu, G.]]
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[[Category: Janjua H]]
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[[Category: Montelione, G T.]]
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[[Category: Liu G]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Montelione GT]]
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[[Category: Shastry, R.]]
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[[Category: Shastry R]]
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[[Category: Tong, S.]]
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[[Category: Tong S]]
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[[Category: Xiao, R.]]
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[[Category: Xiao R]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Structural genomic]]
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[[Category: Transcription]]
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Current revision

Solution NMR Structure of Transcription factor NF-E2 subunit's DNA binding domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR4653B

PDB ID 2kz5

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