2odb

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[[Image:2odb.png|left|200px]]
 
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{{STRUCTURE_2odb| PDB=2odb | SCENE= }}
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==The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6)==
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<StructureSection load='2odb' size='340' side='right'caption='[[2odb]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2odb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ODB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2odb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2odb OCA], [https://pdbe.org/2odb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2odb RCSB], [https://www.ebi.ac.uk/pdbsum/2odb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2odb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/od/2odb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2odb ConSurf].
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<div style="clear:both"></div>
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===The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6)===
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==See Also==
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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==About this Structure==
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== References ==
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[[2odb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODB OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Burgess, N.]]
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[[Category: Arrowsmith C]]
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[[Category: Debreczeni, J E.]]
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[[Category: Burgess N]]
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[[Category: Delft, F von.]]
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[[Category: Debreczeni JE]]
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[[Category: Doyle, D.]]
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[[Category: Doyle D]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Elkins, J.]]
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[[Category: Elkins J]]
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[[Category: Eswaran, J.]]
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[[Category: Eswaran J]]
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[[Category: Gileadi, O.]]
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[[Category: Gileadi O]]
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[[Category: Knapp, S.]]
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[[Category: Knapp S]]
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[[Category: Pike, A C.W.]]
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[[Category: Pike ACW]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Soundararajan M]]
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[[Category: Soundararajan, M.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Ugochukwu E]]
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[[Category: Ugochukwu, E.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Yang X]]
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[[Category: Yang, X.]]
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[[Category: Von Delft F]]
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[[Category: Crib]]
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[[Category: Kinase]]
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[[Category: Protein binding]]
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[[Category: Protein-protein complex]]
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[[Category: Sgc]]
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[[Category: Small gtpase]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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Current revision

The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6)

PDB ID 2odb

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OCA

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