2giv

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[[Image:2giv.png|left|200px]]
 
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{{STRUCTURE_2giv| PDB=2giv | SCENE= }}
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==Human MYST histone acetyltransferase 1==
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<StructureSection load='2giv' size='340' side='right'caption='[[2giv]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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===Human MYST histone acetyltransferase 1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2giv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GIV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[2giv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIV OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2giv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2giv OCA], [https://pdbe.org/2giv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2giv RCSB], [https://www.ebi.ac.uk/pdbsum/2giv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2giv ProSAT]</span></td></tr>
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[[Category: Histone acetyltransferase]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAT8_HUMAN KAT8_HUMAN] Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex.<ref>PMID:12397079</ref> <ref>PMID:15923642</ref> <ref>PMID:20018852</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/2giv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2giv ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards, A M.]]
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[[Category: Bochkarev A]]
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[[Category: Loppnau, P.]]
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[[Category: Edwards AM]]
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[[Category: Min, J.]]
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[[Category: Loppnau P]]
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[[Category: Plotnikov, A N.]]
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[[Category: Min J]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Plotnikov AN]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom M]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Wu, H.]]
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[[Category: Wu H]]
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[[Category: Histone acetyltransferase]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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Current revision

Human MYST histone acetyltransferase 1

PDB ID 2giv

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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