2oix

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[[Image:2oix.png|left|200px]]
 
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{{STRUCTURE_2oix| PDB=2oix | SCENE= }}
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==Xanthomonas XopD C470A Mutant==
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<StructureSection load='2oix' size='340' side='right'caption='[[2oix]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2oix]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_euvesicatoria Xanthomonas euvesicatoria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OIX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oix OCA], [https://pdbe.org/2oix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oix RCSB], [https://www.ebi.ac.uk/pdbsum/2oix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oix ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q3BYJ5_XANC5 Q3BYJ5_XANC5]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oi/2oix_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oix ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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XopD (Xanthomonas outer protein D), a type III secreted effector from Xanthomonas campestris pv. vesicatoria, is a desumoylating enzyme with strict specificity for its plant small ubiquitin-like modifier (SUMO) substrates. Based on SUMO sequence alignments and peptidase assays with various plant, yeast, and mammalian SUMOs, we identified residues in SUMO that contribute to XopD/SUMO recognition. Further predictions regarding the enzyme/substrate specificity were made by solving the XopD crystal structure. By incorporating structural information with sequence alignments and enzyme assays, we were able to elucidate determinants of the rigid SUMO specificity exhibited by the Xanthomonas virulence factor XopD.
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===Xanthomonas XopD C470A Mutant===
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Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases.,Chosed R, Tomchick DR, Brautigam CA, Mukherjee S, Negi VS, Machius M, Orth K J Biol Chem. 2007 Mar 2;282(9):6773-82. Epub 2007 Jan 3. PMID:17204475<ref>PMID:17204475</ref>
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{{ABSTRACT_PUBMED_17204475}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2oix" style="background-color:#fffaf0;"></div>
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[[2oix]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Xanthomonas_euvesicatoria Xanthomonas euvesicatoria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIX OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:017204475</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Xanthomonas euvesicatoria]]
[[Category: Xanthomonas euvesicatoria]]
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[[Category: Brautigam, C A.]]
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[[Category: Brautigam CA]]
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[[Category: Chosed, R.]]
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[[Category: Chosed R]]
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[[Category: Machius, M.]]
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[[Category: Machius M]]
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[[Category: Orth, K.]]
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[[Category: Orth K]]
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[[Category: Tomchick, D R.]]
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[[Category: Tomchick DR]]
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[[Category: Clan ce family 48 cysteine protease]]
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[[Category: Desumoylating enzyme]]
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[[Category: Hydrolase]]
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[[Category: Isopeptidase activity]]
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[[Category: Peptidase activity]]
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[[Category: Secreted virulence facter]]
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[[Category: Type iii secreted effector]]
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Current revision

Xanthomonas XopD C470A Mutant

PDB ID 2oix

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