2k5s

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[[Image:2k5s.png|left|200px]]
 
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{{STRUCTURE_2k5s| PDB=2k5s | SCENE= }}
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==YmoA==
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<StructureSection load='2k5s' size='340' side='right'caption='[[2k5s]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2k5s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2jvp 2jvp]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K5S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k5s OCA], [https://pdbe.org/2k5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k5s RCSB], [https://www.ebi.ac.uk/pdbsum/2k5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k5s ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/YMOA_YERPE YMOA_YERPE] Modulates the thermoregulation of VirF, and hence the yop regulon, as well as the expression of the enterotoxin gene yst. It is supposed to be involved in chromosome structure and DNA topology; probably by means of compaction of DNA (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k5/2k5s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k5s ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The high-resolution solution structure of Yersinia modulating protein YmoA is presented. The protein is all helical with the first three of four helices forming the central core. Structures calculated with only NOE and dihedral restraints exhibit a backbone root-mean-square deviation (rmsd) of 0.77 A. Upon refinement against Halpha-Calpha, HN-N, and Calpha-C' J-modulated residual dipolar couplings, the backbone rmsd improves to 0.22 A. YmoA has a high amino acid sequence identity to and a similar overall fold to Escherichia coli hemolysin expression modulating protein Hha; however, structural differences do occur. YmoA is also found to be structurally similar to the histone-like nucleoid structuring protein H-NS, indicating that YmoA may intercalate into higher-order H-NS suprastructuring by substituting for an H-NS dimer.
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===YmoA===
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The high-precision solution structure of Yersinia modulating protein YmoA provides insight into interaction with H-NS.,McFeeters RL, Altieri AS, Cherry S, Tropea JE, Waugh DS, Byrd RA Biochemistry. 2007 Dec 11;46(49):13975-82. Epub 2007 Nov 15. PMID:18001134<ref>PMID:18001134</ref>
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{{ABSTRACT_PUBMED_18001134}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2k5s" style="background-color:#fffaf0;"></div>
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[[2k5s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2jvp 2jvp]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K5S OCA].
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Yersinia pestis]]
[[Category: Yersinia pestis]]
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[[Category: Byrd, R.]]
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[[Category: Byrd R]]
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[[Category: McFeeters, R L.]]
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[[Category: McFeeters RL]]
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[[Category: Dna-binding]]
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[[Category: Protein]]
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[[Category: Transcription regulator]]
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Current revision

YmoA

PDB ID 2k5s

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