2i8n

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[[Image:2i8n.png|left|200px]]
 
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{{STRUCTURE_2i8n| PDB=2i8n | SCENE= }}
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==Solution structure of the second bromodomain of Brd4==
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<StructureSection load='2i8n' size='340' side='right'caption='[[2i8n]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2i8n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I8N FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i8n OCA], [https://pdbe.org/2i8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i8n RCSB], [https://www.ebi.ac.uk/pdbsum/2i8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i8n ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i8/2i8n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i8n ConSurf].
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<div style="clear:both"></div>
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===Solution structure of the second bromodomain of Brd4===
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
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{{ABSTRACT_PUBMED_018500820}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2i8n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I8N OCA].
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Liu, Y.]]
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[[Category: Large Structures]]
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[[Category: Shi, Y Y.]]
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[[Category: Liu Y]]
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[[Category: Wu, J H.]]
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[[Category: Shi YY]]
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[[Category: 3d structure]]
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[[Category: Wu JH]]
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[[Category: Bromodomain]]
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[[Category: Replication]]
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[[Category: Structural genomic]]
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[[Category: Transcription regulator]]
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Current revision

Solution structure of the second bromodomain of Brd4

PDB ID 2i8n

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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