2k8r

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[[Image:2k8r.png|left|200px]]
 
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{{STRUCTURE_2k8r| PDB=2k8r | SCENE= }}
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==Solution structure of human acidic fibroblast growth factor in complex with anti-angiogenic drug inositol hexaphosphate (IP6)==
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<StructureSection load='2k8r' size='340' side='right'caption='[[2k8r]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2k8r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K8R FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k8r OCA], [https://pdbe.org/2k8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k8r RCSB], [https://www.ebi.ac.uk/pdbsum/2k8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k8r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k8/2k8r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k8r ConSurf].
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<div style="clear:both"></div>
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===Solution structure of human acidic fibroblast growth factor in complex with anti-angiogenic drug inositol hexaphosphate (IP6)===
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==See Also==
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*[[Fibroblast growth factor 3D structures|Fibroblast growth factor 3D structures]]
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{{ABSTRACT_PUBMED_021077672}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2k8r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K8R OCA].
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chin, Y.]]
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[[Category: Large Structures]]
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[[Category: Kumar, S M.]]
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[[Category: Chin Y]]
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[[Category: Mohan, S K.]]
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[[Category: Kumar SM]]
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[[Category: Acidic fibroblast growth factor]]
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[[Category: Mohan SK]]
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[[Category: Angiogenesis]]
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[[Category: Developmental protein]]
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[[Category: Differentiation]]
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[[Category: Growth factor]]
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[[Category: Heparin-binding]]
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[[Category: Hormone]]
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[[Category: Mitogen]]
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Current revision

Solution structure of human acidic fibroblast growth factor in complex with anti-angiogenic drug inositol hexaphosphate (IP6)

PDB ID 2k8r

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