2ggo

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[[Image:2ggo.png|left|200px]]
 
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{{STRUCTURE_2ggo| PDB=2ggo | SCENE= }}
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==Crystal Structure of glucose-1-phosphate thymidylyltransferase from Sulfolobus tokodaii==
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<StructureSection load='2ggo' size='340' side='right'caption='[[2ggo]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ggo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii Sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GGO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ggo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggo OCA], [https://pdbe.org/2ggo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ggo RCSB], [https://www.ebi.ac.uk/pdbsum/2ggo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ggo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/S1PNA_SULTO S1PNA_SULTO] Bifunctional enzyme involved in the synthesis of UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-N-acetylgalactosamine (UDP-GalNAc). It has multiple amino-sugar-1-phosphate acetyltransferase activities, including glucosamine-1-phosphate (GlcN-1-P) acetyltransferase and galactosamine-1-phosphate (GalN-1-P) acetyltransferase activities, and multiple sugar-1-phosphate nucleotidylyltransferase activities, including N-acetylglucosamine-1-phosphate (GlcNAc-1-P) uridyltransferase and N-acetylgalactosamine-1-phosphate (GalNAc-1-P) uridyltransferase activities (PubMed:15598657, PubMed:20400541, PubMed:25567746). Also catalyzes the formation of dTDP-glucose from dTTP and glucose-1-phosphate (Glc-1-P), and the reverse reaction, which produces dTTP from dTDP-glucose and diphosphate (PubMed:15598657). Can also catalyze the formation of UDP-glucose from UTP and glucose-1-phosphate (PubMed:27864169, PubMed:30291121).<ref>PMID:15598657</ref> <ref>PMID:20400541</ref> <ref>PMID:25567746</ref> <ref>PMID:27864169</ref> <ref>PMID:30291121</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gg/2ggo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ggo ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of glucose-1-phosphate thymidylyltransferase from Sulfolobus tokodaii===
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==See Also==
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*[[Glucose-1-phosphate thymidylyltransferase 3D structures|Glucose-1-phosphate thymidylyltransferase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[2ggo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGO OCA].
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__TOC__
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[[Category: Glucose-1-phosphate thymidylyltransferase]]
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</StructureSection>
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[[Category: Sulfolobus tokodaii]]
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[[Category: Large Structures]]
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[[Category: Kuramitsu, S.]]
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[[Category: Sulfurisphaera tokodaii]]
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[[Category: Masui, R.]]
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[[Category: Kuramitsu S]]
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[[Category: Mizushima, T.]]
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[[Category: Masui R]]
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[[Category: Rajakannan, V.]]
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[[Category: Mizushima T]]
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[[Category: Suzuki, A.]]
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[[Category: Rajakannan V]]
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[[Category: Yamane, T.]]
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[[Category: Suzuki A]]
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[[Category: Beta barrel]]
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[[Category: Yamane T]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of glucose-1-phosphate thymidylyltransferase from Sulfolobus tokodaii

PDB ID 2ggo

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