1wfv
From Proteopedia
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| - | [[Image:1wfv.gif|left|200px]]<br /><applet load="1wfv" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1wfv" /> | ||
| - | '''Solution structure of the fifth PDZ domain of human membrane associated guanylate kinase inverted-2 (KIAA0705 protein)'''<br /> | ||
| - | == | + | ==Solution structure of the fifth PDZ domain of human membrane associated guanylate kinase inverted-2 (KIAA0705 protein)== |
| - | + | <StructureSection load='1wfv' size='340' side='right'caption='[[1wfv]]' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[1wfv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WFV FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wfv OCA], [https://pdbe.org/1wfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wfv RCSB], [https://www.ebi.ac.uk/pdbsum/1wfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wfv ProSAT], [https://www.topsan.org/Proteins/RSGI/1wfv TOPSAN]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/MAGI2_HUMAN MAGI2_HUMAN] Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation.<ref>PMID:10760291</ref> | |
| - | [ | + | == Evolutionary Conservation == |
| - | [ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | [ | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/1wfv_consurf.spt"</scriptWhenChecked> |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | [[ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | + | </jmolCheckbox> | |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wfv ConSurf]. | |
| - | + | <div style="clear:both"></div> | |
| - | + | ||
| - | [ | + | |
| - | [[ | + | |
| - | + | ||
| - | + | ==See Also== | |
| + | *[[Guanylate kinase 3D structures|Guanylate kinase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Inoue M]] | ||
| + | [[Category: Kigawa T]] | ||
| + | [[Category: Koshiba S]] | ||
| + | [[Category: Tochio N]] | ||
| + | [[Category: Yokoyama S]] | ||
Current revision
Solution structure of the fifth PDZ domain of human membrane associated guanylate kinase inverted-2 (KIAA0705 protein)
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Categories: Homo sapiens | Large Structures | Inoue M | Kigawa T | Koshiba S | Tochio N | Yokoyama S
