1wgg

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[[Image:1wgg.jpg|left|200px]]<br /><applet load="1wgg" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1wgg" />
 
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'''Solution Structure of the N-terminal Ubiquitin-like Domain of Mouse Ubiquitin Specific Protease 14 (USP14)'''<br />
 
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==About this Structure==
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==Solution Structure of the N-terminal Ubiquitin-like Domain of Mouse Ubiquitin Specific Protease 14 (USP14)==
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1WGG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Active as [http://en.wikipedia.org/wiki/Ubiquitin_thiolesterase Ubiquitin thiolesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.15 3.1.2.15] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WGG OCA].
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<StructureSection load='1wgg' size='340' side='right'caption='[[1wgg]]' scene=''>
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[[Category: Mus musculus]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[1wgg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WGG FirstGlance]. <br>
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[[Category: Ubiquitin thiolesterase]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Inoue, M.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wgg OCA], [https://pdbe.org/1wgg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wgg RCSB], [https://www.ebi.ac.uk/pdbsum/1wgg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wgg ProSAT], [https://www.topsan.org/Proteins/RSGI/1wgg TOPSAN]</span></td></tr>
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[[Category: Kigawa, T.]]
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</table>
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[[Category: Koshiba, S.]]
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== Function ==
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[https://www.uniprot.org/uniprot/UBP14_MOUSE UBP14_MOUSE] Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Maintains the cellular levels of monomeric ubiquitin in cells. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor cxcr4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1.<ref>PMID:16190881</ref> <ref>PMID:19726649</ref>
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[[Category: Tomizawa, T.]]
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== Evolutionary Conservation ==
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[[Category: Yokoyama, S.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Zhao, C.]]
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Check<jmol>
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[[Category: riken structural genomics/proteomics initiative]]
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<jmolCheckbox>
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[[Category: rsgi]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wg/1wgg_consurf.spt"</scriptWhenChecked>
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[[Category: structural genomics]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: ubiquitin specific protease 14]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: ubiquitin-like fold]]
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</jmolCheckbox>
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[[Category: usp14]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wgg ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:44:00 2008''
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==See Also==
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*[[Thioesterase 3D structures|Thioesterase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Inoue M]]
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[[Category: Kigawa T]]
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[[Category: Koshiba S]]
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[[Category: Tomizawa T]]
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[[Category: Yokoyama S]]
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[[Category: Zhao C]]

Current revision

Solution Structure of the N-terminal Ubiquitin-like Domain of Mouse Ubiquitin Specific Protease 14 (USP14)

PDB ID 1wgg

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