2iub

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[[Image:2iub.png|left|200px]]
 
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{{STRUCTURE_2iub| PDB=2iub | SCENE= }}
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==Crystal structure of a divalent metal ion transporter CorA at 2.9 A resolution.==
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<StructureSection load='2iub' size='340' side='right'caption='[[2iub]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2iub]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IUB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iub OCA], [https://pdbe.org/2iub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iub RCSB], [https://www.ebi.ac.uk/pdbsum/2iub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iub ProSAT], [https://www.topsan.org/Proteins/JCSG/2iub TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CORA_THEMA CORA_THEMA] Mediates influx of magnesium ions (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iu/2iub_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iub ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CorA family members are ubiquitously distributed transporters of divalent metal cations and are considered to be the primary Mg2+ transporter of Bacteria and Archaea. We have determined a 2.9 angstrom resolution structure of CorA from Thermotoga maritima that reveals a pentameric cone-shaped protein. Two potential regulatory metal binding sites are found in the N-terminal domain that bind both Mg2+ and Co2+. The structure of CorA supports an efflux system involving dehydration and rehydration of divalent metal ions potentially mediated by a ring of conserved aspartate residues at the cytoplasmic entrance and a carbonyl funnel at the periplasmic side of the pore.
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===CRYSTAL STRUCTURE OF A DIVALENT METAL ION TRANSPORTER CORA AT 2.9 A RESOLUTION.===
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Crystal structure of a divalent metal ion transporter CorA at 2.9 angstrom resolution.,Eshaghi S, Niegowski D, Kohl A, Martinez Molina D, Lesley SA, Nordlund P Science. 2006 Jul 21;313(5785):354-7. PMID:16857941<ref>PMID:16857941</ref>
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{{ABSTRACT_PUBMED_16857941}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2iub" style="background-color:#fffaf0;"></div>
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[[2iub]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUB OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016857941</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: Eshaghi, S.]]
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[[Category: Eshaghi S]]
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[[Category: Kohl, A.]]
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[[Category: Kohl A]]
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[[Category: Lesley, S A.]]
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[[Category: Lesley SA]]
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[[Category: Molina, D Martinez.]]
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[[Category: Martinez Molina D]]
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[[Category: Niegowski, D.]]
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[[Category: Niegowski D]]
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[[Category: Nordlund, P.]]
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[[Category: Nordlund P]]
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[[Category: Cora]]
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[[Category: Divalent cation]]
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[[Category: Ion transporter]]
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[[Category: Membrane protein]]
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Current revision

Crystal structure of a divalent metal ion transporter CorA at 2.9 A resolution.

PDB ID 2iub

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