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1whc

From Proteopedia

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[[Image:1whc.gif|left|200px]]<br /><applet load="1whc" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1whc" />
 
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'''Solution Structure of RSGI RUH-027, a UBA domain from Mouse cDNA'''<br />
 
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==About this Structure==
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==Solution Structure of RSGI RUH-027, a UBA domain from Mouse cDNA==
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1WHC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHC OCA].
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<StructureSection load='1whc' size='340' side='right'caption='[[1whc]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1whc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WHC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1whc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1whc OCA], [https://pdbe.org/1whc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1whc RCSB], [https://www.ebi.ac.uk/pdbsum/1whc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1whc ProSAT], [https://www.topsan.org/Proteins/RSGI/1whc TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UBXN1_MOUSE UBXN1_MOUSE] Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer (By similarity) Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems.<ref>PMID:16709668</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wh/1whc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1whc ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Doi-Katayama Y]]
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[[Category: Doi-Katayama, Y.]]
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[[Category: Hirota H]]
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[[Category: Hirota, H.]]
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[[Category: Kigawa T]]
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[[Category: Kigawa, T.]]
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[[Category: Koshiba S]]
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[[Category: Koshiba, S.]]
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[[Category: Onuki H]]
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[[Category: Onuki, H.]]
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[[Category: Tomizawa T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Yokoyama S]]
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[[Category: Tomizawa, T.]]
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[[Category: Yokoyama, S.]]
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[[Category: mus musculus]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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[[Category: uba domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:44:19 2008''
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Current revision

Solution Structure of RSGI RUH-027, a UBA domain from Mouse cDNA

PDB ID 1whc

Drag the structure with the mouse to rotate

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