2k7r

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[[Image:2k7r.png|left|200px]]
 
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{{STRUCTURE_2k7r| PDB=2k7r | SCENE= }}
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==N-terminal domain of the Bacillus subtilis helicase-loading protein DnaI==
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<StructureSection load='2k7r' size='340' side='right'caption='[[2k7r]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2k7r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K7R FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k7r OCA], [https://pdbe.org/2k7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k7r RCSB], [https://www.ebi.ac.uk/pdbsum/2k7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k7r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DNAI_BACSU DNAI_BACSU] Probably involved in DNA replication.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/2k7r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k7r ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The helicase loader protein DnaI (the Bacillus subtilis homologue of Escherichia coli DnaC) is required to load the hexameric helicase DnaC (the B. subtilis homologue of E. coli DnaB) onto DNA at the start of replication. While the C-terminal domain of DnaI belongs to the structurally well-characterized AAA+ family of ATPases, the structure of the N-terminal domain, DnaI-N, has no homology to a known structure. Three-dimensional structure determination by nuclear magnetic resonance (NMR) spectroscopy shows that DnaI presents a novel fold containing a structurally important zinc ion. Surface plasmon resonance experiments indicate that DnaI-N is largely responsible for binding of DnaI to the hexameric helicase from B. stearothermophilus, which is a close homologue of the corresponding much less stable B. subtilis helicase.
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===N-terminal domain of the Bacillus subtilis helicase-loading protein DnaI===
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A novel zinc-binding fold in the helicase interaction domain of the Bacillus subtilis DnaI helicase loader.,Loscha KV, Jaudzems K, Ioannou C, Su XC, Hill FR, Otting G, Dixon NE, Liepinsh E Nucleic Acids Res. 2009 Apr;37(7):2395-404. Epub 2009 Mar 2. PMID:19255093<ref>PMID:19255093</ref>
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{{ABSTRACT_PUBMED_19255093}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2k7r" style="background-color:#fffaf0;"></div>
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[[2k7r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K7R OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:019255093</ref><references group="xtra"/>
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Dixon, N E.]]
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[[Category: Large Structures]]
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[[Category: Hill, F R.]]
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[[Category: Dixon NE]]
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[[Category: Ioannou, C.]]
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[[Category: Hill FR]]
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[[Category: Jaudzems, K.]]
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[[Category: Ioannou C]]
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[[Category: Liepinsh, E.]]
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[[Category: Jaudzems K]]
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[[Category: Loscha, K V.]]
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[[Category: Liepinsh E]]
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[[Category: Otting, G.]]
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[[Category: Loscha KV]]
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[[Category: Su, X C.]]
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[[Category: Otting G]]
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[[Category: Atp-binding]]
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[[Category: Su XC]]
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[[Category: Dna replication]]
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[[Category: Dnai n-terminal domain]]
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[[Category: Helicase-loading protein]]
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[[Category: Nucleotide-binding]]
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[[Category: Primosome]]
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[[Category: Replication]]
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Current revision

N-terminal domain of the Bacillus subtilis helicase-loading protein DnaI

PDB ID 2k7r

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