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1gzq

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[[Image:1gzq.gif|left|200px]]<br />
 
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<applet load="1gzq" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1gzq, resolution 2.26&Aring;" />
 
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'''CD1B IN COMPLEX WITH PHOPHATIDYLINOSITOL'''<br />
 
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==Overview==
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==CD1b in complex with Phophatidylinositol==
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The human genome encodes five nonpolymorphic major histocompatibility, complex class I-like glycoproteins, CD1a to CD1e, that present lipid, antigens for specific recognition by T lymphocytes. Using single alkyl, chain detergents, we developed a protocol to generate recombinant human, CD1b-lipid complexes. We present here the crystal structures of CD1b in, complex with either phosphatidylinositol or ganglioside GM2 at 2.3 A and, 2.8 A resolutions, respectively. The antigen-binding groove houses four, interlinked hydrophobic channels that are occupied by the alkyl chains of, the glycolipid plus two detergent molecules. A distinct exit beneath the, alpha 2 helix further contributes to the plasticity of the binding groove., These structures reveal the mechanism by which two alkyl chain ... [[http://ispc.weizmann.ac.il/pmbin/getpm?12118248 (full description)]]
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<StructureSection load='1gzq' size='340' side='right'caption='[[1gzq]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1gzq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GZQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=PII:2-[(HYDROXY{[(2R,3R,5S,6R)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL]OXY}PHOSPHORYL)OXY]-1-[(PALMITOYLOXY)METHYL]ETHYL+HEPTADECANOATE'>PII</scene>, <scene name='pdbligand=TWT:DOCOSANE'>TWT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gzq OCA], [https://pdbe.org/1gzq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gzq RCSB], [https://www.ebi.ac.uk/pdbsum/1gzq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gzq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CD1B_HUMAN CD1B_HUMAN] Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:10981968</ref> <ref>PMID:14716313</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gz/1gzq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gzq ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1GZQ is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NO3, PII, D12 and TWT as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GZQ OCA]].
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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*[[CD1|CD1]]
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==Reference==
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== References ==
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Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains., Gadola SD, Zaccai NR, Harlos K, Shepherd D, Castro-Palomino JC, Ritter G, Schmidt RR, Jones EY, Cerundolo V, Nat Immunol. 2002 Aug;3(8):721-6. Epub 2002 Jul 15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12118248 12118248]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Cerundolo, V.]]
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[[Category: Cerundolo V]]
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[[Category: Gadola, S.D.]]
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[[Category: Gadola SD]]
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[[Category: Harlos, K.]]
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[[Category: Harlos K]]
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[[Category: Jones, E.Y.]]
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[[Category: Jones EY]]
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[[Category: Ritter, G.]]
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[[Category: Ritter G]]
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[[Category: Schmidt, R.R.]]
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[[Category: Schmidt RR]]
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[[Category: Shepherd, D.]]
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[[Category: Shepherd D]]
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[[Category: Zaccai, N.R.]]
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[[Category: Zaccai NR]]
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[[Category: D12]]
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[[Category: NO3]]
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[[Category: PII]]
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[[Category: TWT]]
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[[Category: antigen presentation]]
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[[Category: glycoprotein]]
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[[Category: mhc]]
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[[Category: phophatidylinositol]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:23:51 2007''
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Current revision

CD1b in complex with Phophatidylinositol

PDB ID 1gzq

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