2g8y

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[[Image:2g8y.png|left|200px]]
 
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{{STRUCTURE_2g8y| PDB=2g8y | SCENE= }}
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==The structure of a putative malate/lactate dehydrogenase from E. coli.==
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<StructureSection load='2g8y' size='340' side='right'caption='[[2g8y]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2g8y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G8Y FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g8y OCA], [https://pdbe.org/2g8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g8y RCSB], [https://www.ebi.ac.uk/pdbsum/2g8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g8y ProSAT], [https://www.topsan.org/Proteins/MCSG/2g8y TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HCXB_ECOLI HCXB_ECOLI] Catalyzes the NAD(P)H-dependent reduction of 2-oxoglutarate, phenylpyruvate and (4-hydroxyphenyl)pyruvate, leading to the respective 2-hydroxycarboxylate in vitro. Shows a preference for NADPH over NADH as a redox partner. Do not catalyze the reverse reactions.<ref>PMID:27941785</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/2g8y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g8y ConSurf].
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<div style="clear:both"></div>
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===The structure of a putative malate/lactate dehydrogenase from E. coli.===
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==See Also==
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*[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[2g8y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G8Y OCA].
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__TOC__
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[[Category: Escherichia coli k-12]]
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</StructureSection>
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[[Category: Cuff, M E.]]
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[[Category: Escherichia coli K-12]]
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[[Category: Cymborowski, M.]]
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[[Category: Large Structures]]
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[[Category: Edwards, A.]]
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[[Category: Cuff ME]]
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[[Category: Joachimiak, A.]]
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[[Category: Cymborowski M]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Edwards A]]
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[[Category: Minor, W.]]
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[[Category: Joachimiak A]]
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[[Category: Savchenko, A.]]
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[[Category: Minor W]]
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[[Category: Skarina, T.]]
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[[Category: Savchenko A]]
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[[Category: Dehydrogenase]]
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[[Category: Skarina T]]
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[[Category: E coli]]
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[[Category: Lactate]]
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[[Category: Malate]]
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[[Category: Mcsg]]
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[[Category: Midwest center for structural genomic]]
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[[Category: Nad]]
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[[Category: Oxidoreductase]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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Current revision

The structure of a putative malate/lactate dehydrogenase from E. coli.

PDB ID 2g8y

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