2jln

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[[Image:2jln.png|left|200px]]
 
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{{STRUCTURE_2jln| PDB=2jln | SCENE= }}
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==Structure of Mhp1, a nucleobase-cation-symport-1 family transporter==
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<StructureSection load='2jln' size='340' side='right'caption='[[2jln]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2jln]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Microbacterium_liquefaciens Microbacterium liquefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JLN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JLN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jln OCA], [https://pdbe.org/2jln PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jln RCSB], [https://www.ebi.ac.uk/pdbsum/2jln PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jln ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HYUP_MICLQ HYUP_MICLQ] Nucleobase-proton symporter that mediates the sodium-dependent binding and uptake of 5-aryl-substituted hydantoin compounds (PubMed:16621827, PubMed:24952894). 5-indolyl methyl hydantoin and 5-benzyl hydantoin are the preferred substrates, with selectivity for a hydrophobic substituent in position 5 of hydantoin and for the L isomer over the D isomer (PubMed:16621827, PubMed:24952894).<ref>PMID:16621827</ref> <ref>PMID:24952894</ref> <ref>PMID:16116274</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/2jln_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jln ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The 'Nucleobase-Cation-Symport-1', NCS1, transporters are essential components of salvage pathways for nucleobases and related metabolites. Here, we report the 2.85 A resolution structure of the NCS1 benzyl-hydantoin transporter, Mhp1, from Microbacterium liquefaciens. Mhp1 contains 12 transmembrane helices, 10 of which are arranged in two inverted repeats of 5 helices. The structures of the outward-facing open and substrate-bound occluded conformations were solved, showing how the outward-facing cavity closes upon binding of substrate. Comparisons with the leucine (LeuTAa) and the galactose (vSGLT) transporters reveal that the outward- and inward-facing cavities are symmetrically arranged on opposite sides of the membrane. The reciprocal opening and closing of these cavities is synchronised by the inverted repeat helices 3 and 8, providing the structural basis of the 'alternating access' model for membrane transport.
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===STRUCTURE OF MHP1, A NUCLEOBASE-CATION-SYMPORT-1 FAMILY TRANSPORTER===
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Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter.,Weyand S, Shimamura T, Yajima S, Suzuki S, Mirza O, Krusong K, Carpenter EP, Rutherford NG, Hadden JM, O'Reilly J, Ma P, Saidijam M, Patching SG, Hope RJ, Norbertczak HT, Roach PC, Iwata S, Henderson PJ, Cameron AD Science. 2008 Oct 16. PMID:18927357<ref>PMID:18927357</ref>
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{{ABSTRACT_PUBMED_18927357}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2jln" style="background-color:#fffaf0;"></div>
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[[2jln]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Microbacterium_liquefaciens Microbacterium liquefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JLN OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:018927357</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Microbacterium liquefaciens]]
[[Category: Microbacterium liquefaciens]]
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[[Category: Cameron, A D.]]
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[[Category: Cameron AD]]
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[[Category: Carpenter, E P.]]
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[[Category: Carpenter EP]]
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[[Category: Hadden, J M.]]
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[[Category: Hadden JM]]
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[[Category: Henderson, P J.F.]]
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[[Category: Henderson PJF]]
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[[Category: Hope, R J.]]
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[[Category: Hope RJ]]
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[[Category: Iwata, S.]]
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[[Category: Iwata S]]
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[[Category: Krusong, K.]]
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[[Category: Krusong K]]
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[[Category: Ma, P.]]
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[[Category: Ma P]]
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[[Category: Mirza, O.]]
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[[Category: Mirza O]]
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[[Category: Norbertczak, H T.]]
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[[Category: Norbertczak HT]]
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[[Category: Patching, S G.]]
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[[Category: O'Reilly J]]
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[[Category: Reilly, J O.]]
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[[Category: Patching SG]]
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[[Category: Roach, P C.J.]]
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[[Category: Roach PCJ]]
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[[Category: Rutherford, N G.]]
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[[Category: Rutherford NG]]
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[[Category: Saidijam, M.]]
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[[Category: Saidijam M]]
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[[Category: Shimamura, T.]]
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[[Category: Shimamura T]]
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[[Category: Suzuki, S.]]
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[[Category: Suzuki S]]
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[[Category: Weyand, S.]]
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[[Category: Weyand S]]
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[[Category: Yajima, S.]]
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[[Category: Yajima S]]
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[[Category: Hydantoin]]
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[[Category: Membrane protein]]
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[[Category: Nucleobase-cation-symport-1 family]]
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[[Category: Transporter]]
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Current revision

Structure of Mhp1, a nucleobase-cation-symport-1 family transporter

PDB ID 2jln

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