2il1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2il1" [edit=sysop:move=sysop])
Current revision (10:13, 30 August 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2il1.png|left|200px]]
 
-
{{STRUCTURE_2il1| PDB=2il1 | SCENE= }}
+
==Crystal structure of a predicted human GTPase in complex with GDP==
 +
<StructureSection load='2il1' size='340' side='right'caption='[[2il1]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2il1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IL1 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2il1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il1 OCA], [https://pdbe.org/2il1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2il1 RCSB], [https://www.ebi.ac.uk/pdbsum/2il1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2il1 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RAB12_HUMAN RAB12_HUMAN] The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/il/2il1_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2il1 ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of a predicted human GTPase in complex with GDP===
+
==See Also==
-
 
+
*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
[[2il1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL1 OCA].
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Large Structures]]
-
[[Category: Bochkarev, A.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Edwards, A M.]]
+
[[Category: Bochkarev A]]
-
[[Category: Landry, R.]]
+
[[Category: Edwards AM]]
-
[[Category: Park, H.]]
+
[[Category: Landry R]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Park H]]
-
[[Category: Shen, Y.]]
+
[[Category: Shen Y]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Sundstrom M]]
-
[[Category: Tempel, W.]]
+
[[Category: Tempel W]]
-
[[Category: Wang, J.]]
+
[[Category: Wang J]]
-
[[Category: Weigelt, J.]]
+
[[Category: Weigelt J]]
-
[[Category: G-protein]]
+
-
[[Category: Gdp]]
+
-
[[Category: Gtpase]]
+
-
[[Category: Predicted]]
+
-
[[Category: Protein transport]]
+
-
[[Category: Rab]]
+
-
[[Category: Sgc]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural genomics consortium]]
+

Current revision

Crystal structure of a predicted human GTPase in complex with GDP

PDB ID 2il1

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2il1"
Personal tools