2p7v

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[[Image:2p7v.png|left|200px]]
 
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{{STRUCTURE_2p7v| PDB=2p7v | SCENE= }}
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==Crystal structure of the Escherichia coli regulator of sigma 70, Rsd, in complex with sigma 70 domain 4==
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<StructureSection load='2p7v' size='340' side='right'caption='[[2p7v]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2p7v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P7V FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7v OCA], [https://pdbe.org/2p7v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p7v RCSB], [https://www.ebi.ac.uk/pdbsum/2p7v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7v ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RSD_ECOLI RSD_ECOLI] Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.<ref>PMID:9560209</ref> <ref>PMID:10368152</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/2p7v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p7v ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the Escherichia coli regulator of sigma 70, Rsd, in complex with sigma 70 domain 4===
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==See Also==
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*[[Sigma factor 3D structures|Sigma factor 3D structures]]
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{{ABSTRACT_PUBMED_17681541}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2p7v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7V OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:017681541</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Campbell, E A.]]
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[[Category: Large Structures]]
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[[Category: Darst, S A.]]
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[[Category: Campbell EA]]
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[[Category: Lamour, V.]]
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[[Category: Darst SA]]
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[[Category: Lane, W J.]]
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[[Category: Lamour V]]
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[[Category: Patikoglou, G A.]]
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[[Category: Lane WJ]]
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[[Category: Westblade, L F.]]
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[[Category: Patikoglou GA]]
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[[Category: E. coli rsd-sigma 70 complex]]
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[[Category: Westblade LF]]
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[[Category: Escherichia coli rsd-sigma 70 complex]]
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[[Category: Helix-turn-helix]]
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[[Category: Regulation]]
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[[Category: Regulator of sigma 70]]
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[[Category: Rsd]]
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[[Category: Rsd-sigma 70 complex]]
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[[Category: Sigma 70]]
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[[Category: Sigma 70 domain 4]]
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[[Category: Sigma factor]]
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[[Category: Transcription]]
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Current revision

Crystal structure of the Escherichia coli regulator of sigma 70, Rsd, in complex with sigma 70 domain 4

PDB ID 2p7v

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