2jli

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[[Image:2jli.png|left|200px]]
 
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{{STRUCTURE_2jli| PDB=2jli | SCENE= }}
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==Atomic resolution structure of the cytoplasmic domain of Yersinia pestis YscU, a regulatory switch involved in type III secretion==
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<StructureSection load='2jli' size='340' side='right'caption='[[2jli]], [[Resolution|resolution]] 1.13&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2jli]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JLI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JLI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.13&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jli OCA], [https://pdbe.org/2jli PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jli RCSB], [https://www.ebi.ac.uk/pdbsum/2jli PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jli ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/YSCU_YERPE YSCU_YERPE] Component of the yop secretion machinery (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/2jli_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jli ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Crystal structures of cleaved and uncleaved forms of the YscU cytoplasmic domain, an essential component of the type III secretion system (T3SS) in Yersinia pestis, have been solved by single-wavelength anomolous dispersion and refined with X-ray diffraction data extending up to atomic resolution (1.13 A). These crystallographic studies provide structural insights into the conformational changes induced upon auto-cleavage of the cytoplasmic domain of YscU. The structures indicate that the cleaved fragments remain bound to each other. The conserved NPTH sequence that contains the site of the N263-P264 peptide bond cleavage is found on a beta-turn which, upon cleavage, undergoes a major reorientation of the loop away from the catalytic N263, resulting in altered electrostatic surface features at the site of cleavage. Additionally, a significant conformational change was observed in the N-terminal linker regions of the cleaved and noncleaved forms of YscU which may correspond to the molecular switch that influences substrate specificity. The YscU structures determined here also are in good agreement with the auto-cleavage mechanism described for the flagellar homolog FlhB and E. coli EscU.
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===ATOMIC RESOLUTION STRUCTURE OF THE CYTOPLASMIC DOMAIN OF YERSINIA PESTIS YSCU, A REGULATORY SWITCH INVOLVED IN TYPE III SECRETION===
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Atomic resolution structure of the cytoplasmic domain of Yersinia pestis YscU, a regulatory switch involved in type III secretion.,Lountos GT, Austin BP, Nallamsetty S, Waugh DS Protein Sci. 2009 Jan 6;18(2):467-474. PMID:19165725<ref>PMID:19165725</ref>
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{{ABSTRACT_PUBMED_19165725}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2jli" style="background-color:#fffaf0;"></div>
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[[2jli]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JLI OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:019165725</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Yersinia pestis]]
[[Category: Yersinia pestis]]
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[[Category: Austin, B P.]]
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[[Category: Austin BP]]
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[[Category: Lountos, G T.]]
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[[Category: Lountos GT]]
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[[Category: Nallamsetty, S.]]
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[[Category: Nallamsetty S]]
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[[Category: Waugh, D S.]]
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[[Category: Waugh DS]]
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[[Category: Cell membrane]]
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[[Category: Membrane]]
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[[Category: Protein transport]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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[[Category: Type iii secretion system]]
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[[Category: Virulence]]
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[[Category: Yersinia pesti]]
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Current revision

Atomic resolution structure of the cytoplasmic domain of Yersinia pestis YscU, a regulatory switch involved in type III secretion

PDB ID 2jli

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