2oug

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[[Image:2oug.png|left|200px]]
 
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{{STRUCTURE_2oug| PDB=2oug | SCENE= }}
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==Crystal structure of the RfaH transcription factor at 2.1A resolution==
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<StructureSection load='2oug' size='340' side='right'caption='[[2oug]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2oug]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OUG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oug OCA], [https://pdbe.org/2oug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oug RCSB], [https://www.ebi.ac.uk/pdbsum/2oug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oug ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RFAH_ECOLI RFAH_ECOLI] Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains. Enhances expression of several operons involved in synthesis of lipopolysaccharides, exopolysaccharides, hemolysin, and sex factor. Also negatively controls expression and surface presentation of AG43 and possibly another AG43-independent factor that mediates cell-cell interactions and biofilm formation.<ref>PMID:1584020</ref> <ref>PMID:8606157</ref> <ref>PMID:8951819</ref> <ref>PMID:9171395</ref> <ref>PMID:9426123</ref> <ref>PMID:10660066</ref> <ref>PMID:12007406</ref> <ref>PMID:11983161</ref> <ref>PMID:16452414</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ou/2oug_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oug ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the RfaH transcription factor at 2.1A resolution===
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==See Also==
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
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{{ABSTRACT_PUBMED_17434131}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2oug]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OUG OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:017434131</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Artsimovitch, I.]]
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[[Category: Large Structures]]
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[[Category: Svetlov, V.]]
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[[Category: Artsimovitch I]]
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[[Category: Vassylyev, D G.]]
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[[Category: Svetlov V]]
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[[Category: Vassylyeva, M N.]]
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[[Category: Vassylyev DG]]
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[[Category: Transcription]]
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[[Category: Vassylyeva MN]]
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[[Category: Transcription elongation]]
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[[Category: Transcription factor]]
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[[Category: Transcription pausing]]
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[[Category: Virulence]]
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Current revision

Crystal structure of the RfaH transcription factor at 2.1A resolution

PDB ID 2oug

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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