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2iz9

From Proteopedia

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[[Image:2iz9.png|left|200px]]
 
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{{STRUCTURE_2iz9| PDB=2iz9 | SCENE= }}
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==MS2-RNA HAIRPIN (4ONE -5) COMPLEX==
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<StructureSection load='2iz9' size='340' side='right'caption='[[2iz9]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2iz9]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_MS2 Escherichia phage MS2]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1dzs 1dzs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IZ9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ONE:1-(BETA-D-RIBOFURANOSYL)-PYRIDIN-4-ONE-5-PHOSPHATE'>ONE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iz9 OCA], [https://pdbe.org/2iz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iz9 RCSB], [https://www.ebi.ac.uk/pdbsum/2iz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iz9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAPSD_BPMS2 CAPSD_BPMS2] Self-assembles to form the T=3 icosahedral virus shell that protects the viral nucleic acid. Acts as a translational repressor by binding with high specificity to a single stem-loop structure in the genomic RNA that contains the initiation codon of the gene for the viral replicase. Involved in virus assembly through the interaction between a capsid protein dimer and the multiple packaging signals present in the RNA genome.<ref>PMID:16531233</ref> <ref>PMID:18662904</ref> <ref>PMID:26608810</ref> <ref>PMID:8254664</ref> <ref>PMID:9245600</ref> <ref>PMID:9469847</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iz/2iz9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iz9 ConSurf].
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<div style="clear:both"></div>
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===MS2-RNA HAIRPIN (4ONE-5) COMPLEX===
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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{{ABSTRACT_PUBMED_11095669}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2iz9]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacterio_phage_ms2 Enterobacterio phage ms2]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1dzs 1dzs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZ9 OCA].
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</StructureSection>
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[[Category: Escherichia phage MS2]]
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==Reference==
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[[Category: Large Structures]]
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<ref group="xtra">PMID:011095669</ref><references group="xtra"/>
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[[Category: Adams CJ]]
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[[Category: Enterobacterio phage ms2]]
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[[Category: Beigelman L]]
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[[Category: Adams, C J.]]
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[[Category: Fridborg K]]
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[[Category: Beigelman, L.]]
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[[Category: Grahn E]]
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[[Category: Fridborg, K.]]
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[[Category: Liljas L]]
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[[Category: Grahn, E.]]
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[[Category: Matulic-Adamic J]]
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[[Category: Liljas, L.]]
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[[Category: Stockley PG]]
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[[Category: Matulic-Adamic, J.]]
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[[Category: Stonehouse NJ]]
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[[Category: Stockley, P G.]]
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[[Category: Warriner SL]]
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[[Category: Stonehouse, N J.]]
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[[Category: Warriner, S L.]]
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[[Category: Capsid]]
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[[Category: Hairpin]]
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[[Category: Levivirus]]
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[[Category: Virus]]
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[[Category: Virus-rna complex]]
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[[Category: Virus/rna]]
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Current revision

MS2-RNA HAIRPIN (4ONE -5) COMPLEX

PDB ID 2iz9

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