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2k7o

From Proteopedia

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[[Image:2k7o.png|left|200px]]
 
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{{STRUCTURE_2k7o| PDB=2k7o | SCENE= }}
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==Ca2+-S100B, refined with RDCs==
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<StructureSection load='2k7o' size='340' side='right'caption='[[2k7o]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2k7o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K7O FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k7o OCA], [https://pdbe.org/2k7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k7o RCSB], [https://www.ebi.ac.uk/pdbsum/2k7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k7o ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/S100B_RAT S100B_RAT] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization.<ref>PMID:19910580</ref> <ref>PMID:20351179</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/2k7o_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k7o ConSurf].
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<div style="clear:both"></div>
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===Ca2+-S100B, refined with RDCs===
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==See Also==
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*[[S100 proteins 3D structures|S100 proteins 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[2k7o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K7O OCA].
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Inman, K G.]]
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[[Category: Inman KG]]
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[[Category: Levine, J A.]]
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[[Category: Levine JA]]
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[[Category: Weber, D J.]]
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[[Category: Weber DJ]]
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[[Category: Wright, N T.]]
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[[Category: Wright NT]]
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[[Category: Calcium binding]]
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[[Category: Ef-hand]]
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[[Category: Metal binding protein]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: S100 protein]]
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Current revision

Ca2+-S100B, refined with RDCs

PDB ID 2k7o

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