2nnz

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[[Image:2nnz.png|left|200px]]
 
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{{STRUCTURE_2nnz| PDB=2nnz | SCENE= }}
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==Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus==
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<StructureSection load='2nnz' size='340' side='right'caption='[[2nnz]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2nnz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_DSM_4304 Archaeoglobus fulgidus DSM 4304]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NNZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NNZ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nnz OCA], [https://pdbe.org/2nnz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nnz RCSB], [https://www.ebi.ac.uk/pdbsum/2nnz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nnz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O28042_ARCFU O28042_ARCFU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nn/2nnz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nnz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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AF2241 is a hypothetical protein from Archaeoglobus fulgidus and it belongs to the PFam domain of unknown function 369 (DUF369). NMR structural determination reveals that AF2241 adopts a cyclophilin-like fold, with a beta-barrel core composed of eight beta-strands, one alpha-helix, and one 3(10) helix located at each end of the barrel. The protein displays a high structural similarity to TM1367, another member of DUF369 whose structure has been determined recently by X-ray crystallography. Structural similarity search shows that AF2241 also has a high similarity to human cyclophilin A, however, sequence alignment and electrostatic potential analysis reveal that the residues in the PPIase catalytic site of human cyclophilin A are not conserved in AF2241 or TM1367. Instead, a putative active site of AF2241 maps to a negatively charged pocket composed of 9 conserved residues. Our results suggest that although AF2241 adopts the same fold as the human cyclophilin A, it may have distinct biological function.
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===Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus===
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Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold.,Ai X, Li L, Semesi A, Yee A, Arrowsmith CH, Li SS, Choy WY J Biomol NMR. 2007 Aug;38(4):353-8. Epub 2007 Jul 4. PMID:17610131<ref>PMID:17610131</ref>
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{{ABSTRACT_PUBMED_17610131}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2nnz" style="background-color:#fffaf0;"></div>
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[[2nnz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NNZ OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:017610131</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Archaeoglobus fulgidus]]
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[[Category: Archaeoglobus fulgidus DSM 4304]]
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[[Category: Ai, X.]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Ai X]]
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[[Category: Choy, W Y.]]
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[[Category: Arrowsmith CH]]
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[[Category: Li, S S.C.]]
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[[Category: Choy WY]]
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[[Category: OCSP, Ontario Centre for Structural Proteomics.]]
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[[Category: Li SSC]]
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[[Category: Semesib, A.]]
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[[Category: Semesib A]]
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[[Category: Yee, A.]]
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[[Category: Yee A]]
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[[Category: Beta-barrel]]
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[[Category: Ocsp]]
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[[Category: Ontario centre for structural proteomic]]
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[[Category: Structural genomic]]
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[[Category: Unknown function]]
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Current revision

Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus

PDB ID 2nnz

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OCA

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