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2k1z

From Proteopedia

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[[Image:2k1z.png|left|200px]]
 
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{{STRUCTURE_2k1z| PDB=2k1z | SCENE= }}
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==Solution structure of Par-3 PDZ3==
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<StructureSection load='2k1z' size='340' side='right'caption='[[2k1z]]' scene=''>
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===Solution structure of Par-3 PDZ3===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2k1z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K1Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k1z OCA], [https://pdbe.org/2k1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k1z RCSB], [https://www.ebi.ac.uk/pdbsum/2k1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k1z ProSAT]</span></td></tr>
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[[2k1z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K1Z OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PARD3_RAT PARD3_RAT] Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Targets the phosphatase PTEN to cell junctions.<ref>PMID:18082612</ref> <ref>PMID:18550519</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k1/2k1z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k1z ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Chan, L.]]
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[[Category: Chan L]]
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[[Category: Feng, W.]]
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[[Category: Feng W]]
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[[Category: Wu, H.]]
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[[Category: Wu H]]
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[[Category: Zhang, M.]]
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[[Category: Zhang M]]
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[[Category: Cell cycle]]
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[[Category: Cell division]]
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[[Category: Cell junction]]
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[[Category: Cell polarity]]
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[[Category: Membrane]]
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[[Category: Par-3]]
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[[Category: Pdz domain]]
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[[Category: Phosphoprotein]]
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[[Category: Scaffold protein]]
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[[Category: Signaling protein]]
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[[Category: Tight junction]]
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Current revision

Solution structure of Par-3 PDZ3

PDB ID 2k1z

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OCA

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