2fm8
From Proteopedia
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| - | [[Image:2fm8.png|left|200px]] | ||
| - | + | ==Crystal Structure of the Salmonella Secretion Chaperone InvB in Complex with SipA== | |
| - | + | <StructureSection load='2fm8' size='340' side='right'caption='[[2fm8]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2fm8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FM8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fm8 OCA], [https://pdbe.org/2fm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fm8 RCSB], [https://www.ebi.ac.uk/pdbsum/2fm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fm8 ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[2fm8]] is a 3 chain structure with sequence from [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/SPAK_SALTY SPAK_SALTY] Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone SopA, SopE, SopE2 and SipA.<ref>PMID:16547027</ref> <ref>PMID:16507363</ref> | |
| - | == | + | == Evolutionary Conservation == |
| - | < | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[ | + | Check<jmol> |
| - | [[ | + | <jmolCheckbox> |
| - | [ | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/2fm8_consurf.spt"</scriptWhenChecked> |
| - | [[ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [[ | + | </jmolCheckbox> |
| - | [ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fm8 ConSurf]. |
| - | [[Category: | + | <div style="clear:both"></div> |
| - | [[Category: Salmonella]] | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Salmonella enterica subsp. enterica serovar Typhimurium]] | ||
| + | [[Category: Lilic M]] | ||
| + | [[Category: Stebbins CE]] | ||
| + | [[Category: Vujanac M]] | ||
Current revision
Crystal Structure of the Salmonella Secretion Chaperone InvB in Complex with SipA
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