2ogp

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[[Image:2ogp.png|left|200px]]
 
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{{STRUCTURE_2ogp| PDB=2ogp | SCENE= }}
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==Solution structure of the second PDZ domain of Par-3==
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<StructureSection load='2ogp' size='340' side='right'caption='[[2ogp]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ogp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OGP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ogp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ogp OCA], [https://pdbe.org/2ogp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ogp RCSB], [https://www.ebi.ac.uk/pdbsum/2ogp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ogp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PARD3_RAT PARD3_RAT] Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Targets the phosphatase PTEN to cell junctions.<ref>PMID:18082612</ref> <ref>PMID:18550519</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/og/2ogp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ogp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Multiple PDZ domain scaffold protein Par-3 and phosphoinositides (PIPs) are required for polarity in diverse cell types. We show that the second PDZ domain of Par-3 binds to phosphatidylinositol (PI) lipid membranes with high affinity. We further demonstrate that a large subset of PDZ domains in mammalian genomes are capable of binding to PI lipid membranes, indicating that lipid binding is the second most prevalent interaction mode of PDZ domains known to date. The biochemical and structural basis of Par-3 PDZ2-mediated membrane interaction is characterized in detail. The membrane binding capacity of Par-3 PDZ2 is critical for epithelial cell polarization. Interestingly, the lipid phosphatase PTEN directly binds to the third PDZ domain of Par-3. The concatenation of the PIP-binding PDZ2 and the lipid phosphatase PTEN-binding PDZ3 endows Par-3 as an ideal scaffold protein for integrating PIP signaling events during cellular polarization.
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===Solution structure of the second PDZ domain of Par-3===
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PDZ domains of Par-3 as potential phosphoinositide signaling integrators.,Wu H, Feng W, Chen J, Chan LN, Huang S, Zhang M Mol Cell. 2007 Dec 14;28(5):886-98. PMID:18082612<ref>PMID:18082612</ref>
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{{ABSTRACT_PUBMED_18082612}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2ogp" style="background-color:#fffaf0;"></div>
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[[2ogp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OGP OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:018082612</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Chan, L N.]]
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[[Category: Chan L-N]]
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[[Category: Chen, J.]]
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[[Category: Chen J]]
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[[Category: Feng, W.]]
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[[Category: Feng W]]
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[[Category: Wu, H.]]
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[[Category: Wu H]]
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[[Category: Zhang, M.]]
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[[Category: Zhang M]]
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[[Category: Cell polarity]]
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[[Category: Par-3]]
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[[Category: Pdz domain]]
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[[Category: Signaling protein]]
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Current revision

Solution structure of the second PDZ domain of Par-3

PDB ID 2ogp

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OCA

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