2iks

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[[Image:2iks.png|left|200px]]
 
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{{STRUCTURE_2iks| PDB=2iks | SCENE= }}
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==Crystal structure of N-terminal truncated DNA-binding transcriptional dual regulator from Escherichia coli K12==
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<StructureSection load='2iks' size='340' side='right'caption='[[2iks]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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===Crystal structure of N-terminal truncated DNA-binding transcriptional dual regulator from Escherichia coli K12===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2iks]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IKS FirstGlance]. <br>
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{{ABSTRACT_PUBMED_021239488}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iks OCA], [https://pdbe.org/2iks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iks RCSB], [https://www.ebi.ac.uk/pdbsum/2iks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iks ProSAT], [https://www.topsan.org/Proteins/MCSG/2iks TOPSAN]</span></td></tr>
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[[2iks]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IKS OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/CRA_ECOLI CRA_ECOLI] Global transcriptional regulator, which plays an important role in the regulation of carbon metabolism. Activates transcription of genes encoding biosynthetic and oxidative enzymes (involved in Krebs cycle, glyoxylate shunt and gluconeogenesis, such as ppsA and fbp). Represses genes involved in sugar catabolism, such as fruB, pfkA, pykF and adhE. Binds asymmetrically to the two half-sites of its operator.<ref>PMID:16115199</ref> <ref>PMID:8195118</ref> <ref>PMID:8230205</ref> <ref>PMID:8550429</ref> <ref>PMID:8577250</ref> <ref>PMID:8858581</ref> <ref>PMID:9084760</ref> <ref>PMID:9371462</ref>
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<ref group="xtra">PMID:021239488</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Category: Escherichia coli]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Chang, C.]]
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Check<jmol>
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[[Category: Edwards, A M.]]
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<jmolCheckbox>
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[[Category: Evdokimova, E.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ik/2iks_consurf.spt"</scriptWhenChecked>
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[[Category: Joachimiak, A.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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[[Category: Kagan, O.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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</jmolCheckbox>
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[[Category: Savchenko, A.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iks ConSurf].
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[[Category: Dna-binding transcriptional dual regulator]]
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<div style="clear:both"></div>
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[[Category: Escherichia coli k12]]
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== References ==
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[[Category: Mcsg]]
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<references/>
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[[Category: Midwest center for structural genomic]]
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__TOC__
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[[Category: Protein structure initiative]]
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</StructureSection>
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[[Category: Psi-2]]
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[[Category: Escherichia coli K-12]]
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[[Category: Structural genomic]]
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[[Category: Large Structures]]
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[[Category: Transcription]]
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[[Category: Chang C]]
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[[Category: Edwards AM]]
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[[Category: Evdokimova E]]
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[[Category: Joachimiak A]]
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[[Category: Kagan O]]
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[[Category: Savchenko A]]

Current revision

Crystal structure of N-terminal truncated DNA-binding transcriptional dual regulator from Escherichia coli K12

PDB ID 2iks

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