2gil

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[[Image:2gil.png|left|200px]]
 
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{{STRUCTURE_2gil| PDB=2gil | SCENE= }}
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==Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8 resolution==
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<StructureSection load='2gil' size='340' side='right'caption='[[2gil]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2gil]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GIL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gil OCA], [https://pdbe.org/2gil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gil RCSB], [https://www.ebi.ac.uk/pdbsum/2gil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gil ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAB6A_HUMAN RAB6A_HUMAN] Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/2gil_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gil ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Rab/Ypt GTPases represent a&gt;60 member large family of membrane traffic regulators in eukaryotic cells. Members of this group display intrinsic GTPase activity varying over two orders of magnitude. Here, we show that Rab6A represents the RabGTPase with the slowest spontaneous GTPase activity yet measured (5x10(-6)s(-1)). Due to the very low intrinsic hydrolysis rate we were able to crystallise and solve the structure of the Rab6A:GTP complex to 1.82A resolution. Analysis of the structure suggests that low catalytic activity of the Rab6A might be due to high flexibility of the Switch II region and a low degree of constraint of critically important for catalysis Gln 72.
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===Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8 resolution===
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Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8A resolution.,Bergbrede T, Pylypenko O, Rak A, Alexandrov K J Struct Biol. 2005 Dec;152(3):235-8. Epub 2005 Nov 18. PMID:16332443<ref>PMID:16332443</ref>
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{{ABSTRACT_PUBMED_16332443}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2gil" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[2gil]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIL OCA].
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*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016332443</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Alexandrov, K.]]
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[[Category: Large Structures]]
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[[Category: Bergbrede, T.]]
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[[Category: Alexandrov K]]
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[[Category: Pylypenko, O.]]
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[[Category: Bergbrede T]]
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[[Category: Rak, A.]]
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[[Category: Pylypenko O]]
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[[Category: Gtpase-fold]]
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[[Category: Rak A]]
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[[Category: Protein transport]]
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[[Category: Protein-nucleotide complex]]
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Current revision

Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8 resolution

PDB ID 2gil

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