2hua

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2hua" [edit=sysop:move=sysop])
Current revision (16:37, 13 December 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2hua.png|left|200px]]
 
-
{{STRUCTURE_2hua| PDB=2hua | SCENE= }}
+
==Solution Structure of CSFV IRES Domain IIa==
 +
<StructureSection load='2hua' size='340' side='right'caption='[[2hua]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2hua]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HUA FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hua OCA], [https://pdbe.org/2hua PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hua RCSB], [https://www.ebi.ac.uk/pdbsum/2hua PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hua ProSAT]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Internal ribosome entry site (IRES) RNAs from the hepatitis C virus (HCV) and classical swine fever virus (CSFV) coordinate cap-independent assembly of eukaryotic 48S initiation complexes, consisting of the 40S ribosomal subunit, eukaryotic initiation factor (eIF) 3 and the eIF2/GTP/Met-tRNA(i)(Met) ternary complex. Here, we report that these IRESes also play a functional role during 80S ribosome assembly downstream of 48S complex formation, in promoting eIF5-induced GTP hydrolysis and eIF2/GDP release from the initiation complex. We show that this function is encoded in their independently folded IRES domain II and that it depends both on its characteristic bent conformation and two conserved RNA motifs, an apical hairpin loop and a loop E. Our data suggest a general mode of subunit joining in HCV and HCV-like IRESes.
-
===Solution Structure of CSFV IRES Domain IIa===
+
HCV and CSFV IRES domain II mediate eIF2 release during 80S ribosome assembly.,Locker N, Easton LE, Lukavsky PJ EMBO J. 2007 Feb 7;26(3):795-805. Epub 2007 Jan 25. PMID:17255934<ref>PMID:17255934</ref>
-
{{ABSTRACT_PUBMED_17255934}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 2hua" style="background-color:#fffaf0;"></div>
-
[[2hua]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUA OCA].
+
== References ==
-
[[Category: Easton, L E.]]
+
<references/>
-
[[Category: Locker, N.]]
+
__TOC__
-
[[Category: Lukavsky, P J.]]
+
</StructureSection>
-
[[Category: Rna]]
+
[[Category: Large Structures]]
-
[[Category: Rna hairpin]]
+
[[Category: Easton LE]]
 +
[[Category: Locker N]]
 +
[[Category: Lukavsky PJ]]

Current revision

Solution Structure of CSFV IRES Domain IIa

PDB ID 2hua

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hua"
Personal tools