2g9f

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[[Image:2g9f.png|left|200px]]
 
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{{STRUCTURE_2g9f| PDB=2g9f | SCENE= }}
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==Crystal structure of intein-tagged mouse PNGase C-terminal domain==
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<StructureSection load='2g9f' size='340' side='right'caption='[[2g9f]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2g9f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G9F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9f OCA], [https://pdbe.org/2g9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g9f RCSB], [https://www.ebi.ac.uk/pdbsum/2g9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g9f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NGLY1_MOUSE NGLY1_MOUSE] Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.<ref>PMID:11562482</ref> <ref>PMID:12606569</ref> <ref>PMID:15358861</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g9/2g9f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g9f ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of intein-tagged mouse PNGase C-terminal domain===
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==See Also==
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*[[Peptide N-glycanase|Peptide N-glycanase]]
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{{ABSTRACT_PUBMED_17088551}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2g9f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9F OCA].
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:017088551</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Lennarz, W J.]]
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[[Category: Lennarz WJ]]
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[[Category: Li, G.]]
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[[Category: Li G]]
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[[Category: Schindelin, H.]]
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[[Category: Schindelin H]]
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[[Category: Wang, L.]]
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[[Category: Wang L]]
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[[Category: Zhao, G.]]
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[[Category: Zhao G]]
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[[Category: Zhou, X.]]
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[[Category: Zhou X]]
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[[Category: Beta-sandwich]]
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[[Category: Hydrolase]]
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Current revision

Crystal structure of intein-tagged mouse PNGase C-terminal domain

PDB ID 2g9f

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