2k40

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[[Image:2k40.png|left|200px]]
 
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{{STRUCTURE_2k40| PDB=2k40 | SCENE= }}
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==NMR structure of HESX-1 homeodomain double mutant R31L/E42L==
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<StructureSection load='2k40' size='340' side='right'caption='[[2k40]]' scene=''>
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===NMR structure of HESX-1 homeodomain double mutant R31L/E42L===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2k40]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K40 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_019561080}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k40 OCA], [https://pdbe.org/2k40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k40 RCSB], [https://www.ebi.ac.uk/pdbsum/2k40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k40 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2k40]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K40 OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/HESX1_HUMAN HESX1_HUMAN] Hypothyroidism due to deficient transcription factors involved in pituitary development or function;Combined pituitary hormone deficiencies, genetic forms;Pituitary stalk interruption syndrome;Septo-optic dysplasia;Kallmann syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:9620767</ref> <ref>PMID:11136712</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:11136712</ref> <ref>PMID:17148560</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:11136712</ref> <ref>PMID:14561704</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/HESX1_HUMAN HESX1_HUMAN] Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k4/2k40_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k40 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Asensio, J.]]
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[[Category: Large Structures]]
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[[Category: Bastida, A.]]
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[[Category: Asensio J]]
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[[Category: Gonzalez, C.]]
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[[Category: Bastida A]]
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[[Category: Torrado, M.]]
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[[Category: Gonzalez C]]
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[[Category: Developmental protein]]
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[[Category: Torrado M]]
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[[Category: Disease mutation]]
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[[Category: Dna binding protein]]
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[[Category: Dna-binding]]
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[[Category: Dwarfism]]
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[[Category: Homeobox]]
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[[Category: Nucleus]]
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[[Category: Thermostable homeodomain variant]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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Current revision

NMR structure of HESX-1 homeodomain double mutant R31L/E42L

PDB ID 2k40

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