1wxr

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[[Image:1wxr.gif|left|200px]]<br /><applet load="1wxr" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1wxr, resolution 2.20&Aring;" />
 
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'''Crystal structure of Heme Binding protein, an autotransporter hemoglobine protease from pathogenic Escherichia coli'''<br />
 
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==Overview==
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==Crystal structure of Heme Binding protein, an autotransporter hemoglobine protease from pathogenic Escherichia coli==
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The acquisition of iron is essential for the survival of pathogenic bacteria, which have consequently evolved a wide variety of uptake systems to extract iron and heme from host proteins such as hemoglobin. Hemoglobin protease (Hbp) was discovered as a factor involved in the symbiosis of pathogenic Escherichia coli and Bacteroides fragilis, which cause intra-abdominal abscesses. Released from E. coli, this serine protease autotransporter degrades hemoglobin and delivers heme to both bacterial species. The crystal structure of the complete passenger domain of Hbp (110 kDa) is presented, which is the first structure from this class of serine proteases and the largest parallel beta-helical structure yet solved.
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<StructureSection load='1wxr' size='340' side='right'caption='[[1wxr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1wxr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WXR FirstGlance]. <br>
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1WXR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXR OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxr OCA], [https://pdbe.org/1wxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wxr RCSB], [https://www.ebi.ac.uk/pdbsum/1wxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxr ProSAT]</span></td></tr>
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==Reference==
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</table>
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Crystal structure of hemoglobin protease, a heme binding autotransporter protein from pathogenic Escherichia coli., Otto BR, Sijbrandi R, Luirink J, Oudega B, Heddle JG, Mizutani K, Park SY, Tame JR, J Biol Chem. 2005 Apr 29;280(17):17339-45. Epub 2005 Feb 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15728184 15728184]
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== Function ==
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[https://www.uniprot.org/uniprot/HBP_ECOLX HBP_ECOLX] Interacts with hemoglobin, degrades it and subsequently binds the released heme. Could make heme accessible not only for E.coli, but also for B.fragilis during mixed intra-abdominal infections. Has a role in abscess formation.<ref>PMID:9743528</ref> <ref>PMID:11748157</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wx/1wxr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wxr ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Heddle, J G.]]
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[[Category: Heddle JG]]
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[[Category: Luirink, J.]]
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[[Category: Luirink J]]
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[[Category: Mizutani, K.]]
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[[Category: Mizutani K]]
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[[Category: Otto, B R.]]
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[[Category: Otto BR]]
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[[Category: Oudega, B.]]
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[[Category: Oudega B]]
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[[Category: Park, S Y.]]
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[[Category: Park S-Y]]
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[[Category: Sijbrandi, R.]]
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[[Category: Sijbrandi R]]
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[[Category: Tame, J R.H.]]
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[[Category: Tame JRH]]
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[[Category: autotransporter]]
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[[Category: beta helix]]
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[[Category: heme uptake]]
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[[Category: hemoglobine protease]]
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[[Category: spate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:49:09 2008''
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Current revision

Crystal structure of Heme Binding protein, an autotransporter hemoglobine protease from pathogenic Escherichia coli

PDB ID 1wxr

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